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Consequences of Fetal Programming for Cardiovascular Disease in Adulthood.
MedLine Citation:
PMID:  21418386     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
This Spotlight Issue of Microcirculation contains six current perspectives on the role of the intrauterine environment, especially maternal nutritional status and maternal diabetes in influencing fetal growth and cardiovascular heath in the offspring in later life. The reviews address issues such as the existence of a commonality of mechanism following both under- and over nutritional states in utero; alterations in the placental fetal microcirculation in response to maternal and fetal changes; transmission of metabolic or nutritional perturbations affecting fetal endogenous antioxidant defense pathways; the presence of a disadvantageous microvascular phenotype resulting from perinatal priming; interactions between developmental programming and genetic variation in non-communicable adult diseases such as hypertension and hypercholesterolemia; and unresolved questions on the independency and causal mechanisms for low birth weight/intrauterine growth restriction and the risk of metabolic syndrome. These timely reviews highlight the accumulating evidence that changes in the intrauterine environment have pronounced effects on vascular function in the offspring, whether due to maternal diabetes or altered maternal nutritional status or fetal and perinatal overnutrition.
Authors:
Lopa Leach; Giovanni E Mann
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-9
Journal Detail:
Title:  Microcirculation (New York, N.Y. : 1994)     Volume:  -     ISSN:  1549-8719     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9434935     Medline TA:  Microcirculation     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 John Wiley & Sons Ltd.
Affiliation:
Cardiovascular Research Group, School of Biomedical Sciences, Faculty of Medicine and Health Sciences, University of Nottingham, NG7 2UH, United Kingdom Cardiovascular Division, British Heart Foundation Centre of Research Excellence, School of Medicine, King's College London, 150 Stamford Street, London SE1 9NH, United Kingdom.
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