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MedLine Citation:
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PMID: 9558143 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The ideal biomarker for Alzheimer's disease (AD) should detect a fundamental feature of neuropathology and be validated in neuropathologically-confirmed cases; it should have a sensitivity >80% for detecting AD and a specificity of >80% for distinguishing other dementias; it should be reliable, reproducible, non-invasive, simple to perform, and inexpensive. Recommended steps to establish a biomarker include confirmation by at least two independent studies conducted by qualified investigators with the results published in peer-reviewed journals. Our review of current candidate markers indicates that for suspected early-onset familial AD, it is appropriate to search for mutations in the presenilin 1, presenilin 2, and amyloid precursor protein genes. Individuals with these mutations typically have increased levels of the amyloid Abeta42 peptide in plasma and decreased levels of APPs in cerebrospinal fluid. In late-onset and sporadic AD, these measures are not useful, but detecting an apolipoprotein E e4 allele can add confidence to the clinical diagnosis. Among the other proposed molecular and biochemical markers for sporadic AD, cerebrospinal fluid assays showing low levels of Abeta42 and high levels of tau come closest to fulfilling criteria for a useful biomarker. |
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Authors:
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Publication Detail:
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Type: Consensus Development Conference; Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Neurobiology of aging Volume: 19 ISSN: 0197-4580 ISO Abbreviation: Neurobiol. Aging Publication Date: 1998 Mar-Apr |
Date Detail:
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Created Date: 1998-06-12 Completed Date: 1998-06-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8100437 Medline TA: Neurobiol Aging Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 109-16 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Alzheimer Disease / diagnosis*, metabolism* Biological Markers Humans Molecular Biology Nerve Tissue Proteins / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Nerve Tissue Proteins |
| Comments/Corrections | |
Comment In:
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Neurobiol Aging. 1999 Mar-Apr;20(2):247
[PMID:
10537034
]
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Erratum In:
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Neurobiol Aging 1998 May-Jun;19(3):285 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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