Document Detail

Conscious obese rats have impaired reflex bradycardia and enhanced norepinephrine sensitivity.
MedLine Citation:
PMID:  8853388     Owner:  NLM     Status:  MEDLINE    
Male Sprague-Dawley rats fed a condensed milk diet were classified as either "obesity susceptible" (OS) or "obesity resistant" (OR) based on body weight increases attained after 12 wk. Overall caloric intake in OS rats was higher than in chow-fed controls, and OS rats were heavier than chow-fed controls or OR rats. There were no significant differences in blood glucose, serum insulin, ventricular weight, basal blood pressure, or heart rate. Pressor responses recorded after combined blockade with atropine and propranolol to eliminate reflex effects were identical for vasopressin, but those to norepinephrine were larger in OS than in OR rats, whereas those to angiotensin were larger in OS than in control rats. When baroreflex sensitivity was assessed using intravenously infused sodium nitroprusside or phenylephrine to alter systemic arterial pressure, differences in reflex tachycardia were equivocal, but reflex bradycardia was clearly inhibited in OS rats. These results show that, although basal blood pressure was unaffected in OS rats, their impaired reflex bradycardia along with enhanced pressor responsiveness to norepinephrine could predispose them to subsequent development of hypertension.
R D Buñag; M Meyer; N Vansell; L Kerecsen
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  271     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1996 Sep 
Date Detail:
Created Date:  1996-12-05     Completed Date:  1996-12-05     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  R654-60     Citation Subset:  IM    
Department of Pharmacology, Toxicology and Therapeutics, College of Health Sciences and Hospital, University of Kansas Medical Center, Kansas City 66160, USA.
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MeSH Terms
Adipose Tissue / anatomy & histology
Adrenergic beta-Antagonists / pharmacology
Blood Pressure / drug effects
Cardiovascular System / physiopathology
Cholinergic Antagonists / pharmacology
Disease Susceptibility
Drug Resistance
Energy Intake
Heart Rate* / drug effects
Nitroprusside / pharmacology
Norepinephrine / pharmacology*
Obesity / etiology,  physiopathology*
Phenylephrine / pharmacology
Reflex* / drug effects
Weight Gain
Grant Support
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Cholinergic Antagonists; 15078-28-1/Nitroprusside; 51-41-2/Norepinephrine; 59-42-7/Phenylephrine

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