Document Detail

Consanguinity and recurrence risk of stillbirth and infant death.
MedLine Citation:
PMID:  10191794     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: The aim of this study was to estimate the recurrence risk for stillbirth and infant death and compare results for offspring of first-cousin parents with results for offspring of unrelated parents. METHODS: The study population consisted of all single births with a previous sibling born in Norway between 1967 and 1994. Altogether, 629,888 births were to unrelated parents, and 3466 births were to parents who were first cousins. The risk of stillbirth and infant death was estimated for subsequent siblings contingent on parental consanguinity and survival of the previous sibling. RESULTS: For unrelated parents, the risk of early death (stillbirth plus infant death) for the subsequent sibling was 17 of 1000 if the previous child survived and 67 of 1000 if the previous child died before 1 year of age. For parents who were first cousins, the risk of early death for the subsequent sibling was 29 of 1000 if the previous child survived and 116 of 1000 if the previous child died. CONCLUSIONS: The risk of recurrence of stillbirth and infant death is higher for offspring of first-cousin parents compared with offspring of unrelated parents.
C Stoltenberg; P Magnus; A Skrondal; R T Lie
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of public health     Volume:  89     ISSN:  0090-0036     ISO Abbreviation:  Am J Public Health     Publication Date:  1999 Apr 
Date Detail:
Created Date:  1999-04-16     Completed Date:  1999-04-16     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  1254074     Medline TA:  Am J Public Health     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  517-23     Citation Subset:  AIM; IM    
Department of Population Health Sciences, National Institute of Public Health, Oslo, Norway.
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MeSH Terms
Birth Certificates
Case-Control Studies
Fetal Death / epidemiology,  etiology*
Infant Mortality*
Infant, Newborn
Norway / epidemiology
Population Surveillance
Risk Factors
Survival Analysis

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