| Consanguinity, prematurity, birth weight and pregnancy loss: a prospective cohort study at four primary health center areas of Karnataka, India. | |
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MedLine Citation:
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PMID: 21852769 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Objective:To determine whether consanguinity adversely influences pregnancy outcome in South India, where consanguinity is a common means of family property retention.Study Design:Data were collected from a prospective cohort of 647 consenting women, consecutively registered for antenatal care between 14 and 18 weeks gestation, in Belgaum district, Karnataka in 2005. Three-generation pedigree charts were drawn for consanguineous participants. χ (2)-Test and Student's t-test were used to assess categorical and continuous data, respectively, using SPSS version 14. Multivariate logistic regression adjusted for confounding variables.Result:Overall, 24.1% of 601 women with singleton births and outcome data were consanguineous. Demographic characteristics between study groups were similar. Non-consanguineous couples had fewer stillbirths (2.6 vs 6.9% P=0.017; adjusted P=0.050), miscarriages (1.8 vs 4.1%, P=0.097; adjusted P=0.052) and lower incidence of birth weight <2500 g (21.8 vs 29.5%, P=0.071, adjusted P=0.044). Gestation <37 weeks was 6.2% in both the groups. Adjusted for consanguinity and other potential confounders, age <20 years was protective of stillbirth (P=0.01), pregnancy loss (P=0.023) and preterm birth (P=0.013), whereas smoking (P=0.015) and poverty (P=0.003) were associated with higher rates of low birth weight.Conclusion:Consanguinity significantly increases pregnancy loss and birth weight <2500 g.Journal of Perinatology advance online publication, 18 August 2011; doi:10.1038/jp.2011.115. |
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Authors:
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M B Bellad; S S Goudar; S A Edlavitch; N S Mahantshetti; V Naik; J J Hemingway-Foday; M Gupta; H R Nalina; R Derman; N Moss; B S Kodkany |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-18 |
Journal Detail:
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Title: Journal of perinatology : official journal of the California Perinatal Association Volume: - ISSN: 1476-5543 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-8-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8501884 Medline TA: J Perinatol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Medical Education, Jawaharlal Nehru Medical College, Belgaum, India. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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