| Consanguinity and advanced maternal age as risk factors for reproductive losses in Alexandria, Egypt. | |
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MedLine Citation:
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PMID: 11949729 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Consanguinity has been a long-standing social habit among Egyptians. Estimates of consanguinity ratios in different parts of Egypt ranged from 29 to 50%. This study aimed at delineating the role of consanguinity and advanced maternal age on reproductive losses in Alexandria, Egypt. METHODS: A case-control study, on 730 couples with history of reproductive losses and 2,081 normal couples, was done during the period October, 1998 until August, 2000. RESULTS: Of the 730 couples with reproductive losses, consanguinity frequency was 68.8% with 56.2% first cousins. Prenatal loss and infant deaths were highly encountered among consanguineous marriages (p < 0.0001). In a multivariate logistic regression analysis, consanguinity between couples increased the relative risk of repeated abortion (OR: 3.95; 95% CI: 3.04-5.14), stillbirths (OR: 10.6; 95% CI: 6.7-17.0), neonatal death (OR: 17.2; 95% CI: 10.8-27.3), post-neonatal death (OR: 14.5; 95% CI: 10.6-19.9) and total reproductive losses (OR: 8.3; 95% CI: 6.9-10.1). A positive association was found between advanced maternal age and repeated abortion (OR: 3.19; 95% CI: 2.04-4.97) as well as total reproductive losses (OR: 2.37; 95% CI: 1.74-3.2). CONCLUSION: This study, the largest-reported case-control study on reproductive losses in Alexandria, strongly suggests that consanguinity may play a major role in the high rates of prenatal and infant mortality while advanced maternal age has a significant role in the causation of repeated abortion, and they must be taken into account for genetic counseling in Egypt. Because of the possibility of controlling, the study gives clear indications for prevention. |
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Authors:
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M M Mokhtar; M M Abdel-Fattah |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of epidemiology Volume: 17 ISSN: 0393-2990 ISO Abbreviation: Eur. J. Epidemiol. Publication Date: 2001 |
Date Detail:
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Created Date: 2002-04-12 Completed Date: 2002-05-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8508062 Medline TA: Eur J Epidemiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 559-65 Citation Subset: IM |
Affiliation:
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Department of Huiman Genetics, Medical Research Institute, Alexandria University, Egypt. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Case-Control Studies Consanguinity* Egypt / epidemiology Female Fetal Death / epidemiology, etiology*, genetics Genetic Counseling / methods Humans Infant Mortality Infant, Newborn Logistic Models Male Maternal Age* Middle Aged Pregnancy, High-Risk* |
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