Document Detail


Conotoxin therapeutics: a pipeline for success?
MedLine Citation:
PMID:  23484755     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The pharmacopoeia of conotoxins from the marine snail Conus has evolved with time, providing a myriad of molecular scaffolds on which critical, molecular pharmacophoric descriptors, responsible for mediating conotoxin receptor-target specificity and selectivity have been grafted. Several reports have defined how these critical determinants contribute to refined, subtype-selective receptor recognition. However, the clinical utility of conotoxins is debatable with a single conotoxin, ω-MVIIA (ziconotide), approved by the US FDA. The authors review the present status of conotoxin-based drug discovery efforts, highlighting ongoing preclinical and clinical studies, while discussing strategies that may be necessary to overcome the barriers inherent to peptide therapeutics. Through the beauty of nature and the art of design it should be possible to expand the Conus pipeline.
Authors:
Marianne A Grant; Kumaran Shanmugasundaram; Alan C Rigby
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Expert opinion on drug discovery     Volume:  2     ISSN:  1746-0441     ISO Abbreviation:  Expert Opin Drug Discov     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2013-03-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101295755     Medline TA:  Expert Opin Drug Discov     Country:  England    
Other Details:
Languages:  eng     Pagination:  453-68     Citation Subset:  -    
Affiliation:
Division of Molecular and Vascular Medicine, Department of Medicine, Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA. arigby@bidmc.harvard.edu.
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