| Connexins protect mouse pancreatic β cells against apoptosis. | |
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MedLine Citation:
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PMID: 22056383 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Type 1 diabetes develops when most insulin-producing β cells of the pancreas are killed by an autoimmune attack. The in vivo conditions modulating the sensitivity and resistance of β cells to this attack remain largely obscure. Here, we show that connexin 36 (Cx36), a trans-membrane protein that forms gap junctions between β cells in the pancreatic islets, protects mouse β cells against both cytotoxic drugs and cytokines that prevail in the islet environment at the onset of type 1 diabetes. We documented that this protection was at least partially dependent on intercellular communication, which Cx36 and other types of connexin channels establish within pancreatic islets. We further found that proinflammatory cytokines decreased expression of Cx36 and that experimental reduction or augmentation of Cx36 levels increased or decreased β cell apoptosis, respectively. Thus, we conclude that Cx36 is central to β cell protection from toxic insults. |
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Authors:
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Philippe Klee; Florent Allagnat; Helena Pontes; Manon Cederroth; Anne Charollais; Dorothée Caille; Aurore Britan; Jacques-Antoine Haefliger; Paolo Meda |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2011-11-07 |
Journal Detail:
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Title: The Journal of clinical investigation Volume: 121 ISSN: 1558-8238 ISO Abbreviation: J. Clin. Invest. Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-02 Completed Date: 2012-01-31 Revised Date: 2012-02-07 |
Medline Journal Info:
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Nlm Unique ID: 7802877 Medline TA: J Clin Invest Country: United States |
Other Details:
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Languages: eng Pagination: 4870-9 Citation Subset: AIM; IM |
Affiliation:
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Department of Cell Physiology and Metabolism, University of Geneva, Medical School, Geneva, Switzerland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alloxan
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pharmacology,
toxicity Animals Apoptosis / drug effects Cell Communication Cellular Microenvironment Connexins / antagonists & inhibitors, deficiency, genetics, physiology* Diabetes Mellitus, Experimental / chemically induced, metabolism, pathology, prevention & control* Gap Junctions / physiology Gene Dosage Insulin / genetics Interferon-gamma / toxicity Interleukin-1beta / toxicity Islets of Langerhans / drug effects, metabolism, pathology* Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Nitric Oxide / biosynthesis Promoter Regions, Genetic RNA Interference RNA, Small Interfering / pharmacology Rats Recombinant Fusion Proteins / physiology Streptozocin / pharmacology, toxicity Tumor Necrosis Factor-alpha / toxicity |
| Chemical | |
Reg. No./Substance:
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0/Connexins; 0/Insulin; 0/Interleukin-1beta; 0/RNA, Small Interfering; 0/Recombinant Fusion Proteins; 0/Tumor Necrosis Factor-alpha; 0/connexin 36; 10102-43-9/Nitric Oxide; 18883-66-4/Streptozocin; 50-71-5/Alloxan; 82115-62-6/Interferon-gamma |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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