| Connexins and cardiac arrhythmias. | |
| | |
MedLine Citation:
|
PMID: 16646589 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
During cardiac remodeling, impulse conduction in the heart is altered by changes in excitability, electrical coupling, and tissue architecture. The impairment of normal impulse conduction is one of the factors that increases the propensity for arrhythmias. This chapter focuses on the relationship between electrical coupling between ventricular myocytes and arrhythmogenesis. Mouse models of decreased electrical coupling in the heart have shown that a clinically relevant 50% reduction in gap junctions in the heart has no effect on impulse conduction or arrhythmogenesis. To impair conduction and arrhythmias, coupling has to be reduced to very low levels. Apparently, there is a large conduction reserve, which can preserve normal impulse conduction even when electrical coupling is moderately reduced. However, cardiac remodeling is also associated with reduced excitability and increased levels of collagen deposition (fibrosis). It is therefore presumably the combination of, in itself ineffective, reduction of electrical coupling with other impairments like fibrosis or reduced excitability that causes the limits of conduction reserve to be exceeded, thereby resulting in abnormal impulse conduction and enhanced arrhythmogenesis. |
| | |
Authors:
|
Harold V M van Rijen; Toon A B van Veen; Daniel Gros; Ronald Wilders; Jacques M T de Bakker |
Related Documents
:
|
6827869 - Clinical algorithms for prehospital cardiac care. 2178379 - Effect of diltiazem on cardiac rate and rhythm after myocardial infarction. multicenter... 19964839 - Cardiac arrhythmia classification using wavelets and hidden markov models - a comparati... 19766769 - Frequencies and types of arrhythmias in patients with systemic light-chain amyloidosis ... 19741149 - Inhibition of thromboxane a2-induced arrhythmias and intracellular calcium changes in c... 10535369 - Postoperative atrial arrhythmias: risk factors and associated adverse outcomes. 17365849 - Platelets and white blood cell subpopulations among patients with myocardial infarction... 7887719 - Tepid antegrade and retrograde cardioplegia. 18044459 - Prospective follow-up cardiac evaluation of children with kawasaki disease in northern ... |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Advances in cardiology Volume: 42 ISSN: 0065-2326 ISO Abbreviation: Adv Cardiol Publication Date: 2006 |
Date Detail:
|
Created Date: 2006-05-01 Completed Date: 2006-07-06 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0270063 Medline TA: Adv Cardiol Country: Switzerland |
Other Details:
|
Languages: eng Pagination: 150-60 Citation Subset: IM |
Affiliation:
|
Department of Medical Physiology, University Medical Center Utrecht, Utrecht, The Netherlands. H.V.M.vanRijen@med.uu.nl |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Arrhythmias, Cardiac / physiopathology* Connexins / metabolism, physiology* Gap Junctions / metabolism Heart Conduction System / physiopathology* Humans Models, Animal Tachycardia, Ventricular / physiopathology Ventricular Remodeling / physiology |
| Chemical | |
Reg. No./Substance:
|
0/Connexins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Structural and functional coupling of cardiac myocytes and fibroblasts.
Next Document: Role of connexins in atrial fibrillation.