Document Detail


Connexin43 cardiac gap junction remodeling: lessons from genetically engineered murine models.
MedLine Citation:
PMID:  22722763     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sudden cardiac death is responsible for several hundred thousand deaths each year in the United States. Multiple lines of evidence suggest that perturbation of gap junction expression and function in the heart, or what has come to be known as cardiac gap junction remodeling, plays a key mechanistic role in the pathophysiology of clinically significant cardiac arrhythmias. Here we review recent studies from our laboratory using genetically engineered murine models to explore mechanisms implicated in pathologic gap junction remodeling and their proarrhythmic consequences, with a particular focus on aberrant posttranslational phosphorylation of connexin43.
Authors:
Benjamin F Remo; Steven Giovannone; Glenn I Fishman
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2012-06-22
Journal Detail:
Title:  The Journal of membrane biology     Volume:  245     ISSN:  1432-1424     ISO Abbreviation:  J. Membr. Biol.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-07-23     Completed Date:  2012-12-14     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  0211301     Medline TA:  J Membr Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  275-81     Citation Subset:  IM    
Affiliation:
Leon H. Charney Division of Cardiology, New York University School of Medicine, 522 First Avenue, Smilow 801, New York, NY 10016, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Genetically Modified
Arrhythmias, Cardiac / metabolism
Connexin 43 / metabolism*
Gap Junctions / metabolism*
Humans
Mice
Phosphorylation
Protein Processing, Post-Translational
Grant Support
ID/Acronym/Agency:
R01 HL082727/HL/NHLBI NIH HHS; R01 HL105983/HL/NHLBI NIH HHS; R01 HL82727/HL/NHLBI NIH HHS; T32 HL098129/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Connexin 43
Comments/Corrections

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