Document Detail

Connexin40 is essential for the pressure control of renin synthesis and secretion.
MedLine Citation:
PMID:  17255527     Owner:  NLM     Status:  MEDLINE    
Renin secretion and synthesis in renal juxtaglomerular cells are controlled by short feed back loops involving angiotensin II and the intrarenal blood pressure. The operating mechanisms of these negative feed back regulators are widely unknown, except for the fact that both require calcium to exert their inhibitory action. We here show that in the absence of connexin40 (Cx40), which form gap junctions between juxtaglomerular and endothelial cells, the negative control of renin secretion and synthesis by angiotensin II and by intravasal pressure is abrogated, while the regulation by salt intake and beta-adrenergic stimulation is maintained. Renin secretion from Cx40-deficient kidneys or wild-type kidneys treated with the nonselective gap junction blocker 18alpha-glycyrrhetinic acid (10 micromol/L) resembles the situation in wild-type kidneys in the absence of extracellular calcium. This disturbed regulation is reflected by an enhanced plasma renin concentration despite an elevated blood pressure in Cx40-deficient mice. These findings indicate that Cx40 connexins and likely intercellular communication via Cx40-dependent gap junctions mediate the calcium-dependent inhibitor effects of angiotensin II and of intrarenal pressure on renin secretion and synthesis. Because Cx40 gap junctions are also formed between renin producing cells and endothelial cells our finding could provide additional information to suggest that the endothelium may be strongly involved in the control of the renin system.
Charlotte Wagner; Cor de Wit; Lisa Kurtz; Christian Grünberger; Armin Kurtz; Frank Schweda
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-01-25
Journal Detail:
Title:  Circulation research     Volume:  100     ISSN:  1524-4571     ISO Abbreviation:  Circ. Res.     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-03-02     Completed Date:  2007-03-16     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0047103     Medline TA:  Circ Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  556-63     Citation Subset:  IM    
Physiologisches Institut der Universität Regensburg, Regensburg, Germany.
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MeSH Terms
Angiotensin II / antagonists & inhibitors,  physiology
Blood Pressure / physiology*
Cells, Cultured
Connexins / deficiency,  physiology*
Feedback, Physiological / physiology
Hypertension / metabolism
Kidney / metabolism,  secretion
Mice, Inbred C57BL
Mice, Knockout
Renin / antagonists & inhibitors,  biosynthesis*,  secretion*
Reg. No./Substance:
0/Connexins; 0/connexin 40; 11128-99-7/Angiotensin II; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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