| Connexin 43 and ischemic preconditioning. | |
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MedLine Citation:
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PMID: 15094353 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Connexin 43 (Cx43) is the essential protein to form hemichannels and gap junctions in the myocardium. The phosphorylation status of Cx43 which is regulated by a variety of protein kinases and phosphatases determines hemichannel and/or gap junction conductance and permeability. Gap junctions are involved in cell-cell coupling while hemichannels contribute to cardiomyocyte volume regulation. Cx43-formed channels are involved in ischemia/reperfusion injury, since blockade of a large portion of Cx43-formed channels attenuates ischemic hypercontracture, infarct development and post myocardial infarction remodeling. Ischemic preconditioning's protection also depends on functional Cx43-formed channels, since uncoupling of channels or genetic Cx43 deficiency abolishes infarct size reduction by ischemic preconditioning. The exact underlying mechanism(s) how Cx43 mediates protection remain to be established. |
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Authors:
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Rainer Schulz; Gerd Heusch |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Cardiovascular research Volume: 62 ISSN: 0008-6363 ISO Abbreviation: Cardiovasc. Res. Publication Date: 2004 May |
Date Detail:
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Created Date: 2004-04-19 Completed Date: 2004-09-20 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0077427 Medline TA: Cardiovasc Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 335-44 Citation Subset: IM |
Affiliation:
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Institut für Pathophysiologie, Zentrum für Innere Medizin, Universitätsklinikum Essen, Hufelandstrasse 55, 45122 Essen, Germany. rainer_schulz@uni-essen.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Adhesion Cell Membrane Permeability Connexin 43 / metabolism* Gap Junctions / metabolism* Humans Ion Channels / metabolism* Ischemic Preconditioning, Myocardial* Myocardial Reperfusion Injury / metabolism Myocardium / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Connexin 43; 0/Ion Channels |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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