Document Detail


Connexin 43 and ischemic preconditioning.
MedLine Citation:
PMID:  15094353     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Connexin 43 (Cx43) is the essential protein to form hemichannels and gap junctions in the myocardium. The phosphorylation status of Cx43 which is regulated by a variety of protein kinases and phosphatases determines hemichannel and/or gap junction conductance and permeability. Gap junctions are involved in cell-cell coupling while hemichannels contribute to cardiomyocyte volume regulation. Cx43-formed channels are involved in ischemia/reperfusion injury, since blockade of a large portion of Cx43-formed channels attenuates ischemic hypercontracture, infarct development and post myocardial infarction remodeling. Ischemic preconditioning's protection also depends on functional Cx43-formed channels, since uncoupling of channels or genetic Cx43 deficiency abolishes infarct size reduction by ischemic preconditioning. The exact underlying mechanism(s) how Cx43 mediates protection remain to be established.
Authors:
Rainer Schulz; Gerd Heusch
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Cardiovascular research     Volume:  62     ISSN:  0008-6363     ISO Abbreviation:  Cardiovasc. Res.     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-04-19     Completed Date:  2004-09-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0077427     Medline TA:  Cardiovasc Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  335-44     Citation Subset:  IM    
Affiliation:
Institut für Pathophysiologie, Zentrum für Innere Medizin, Universitätsklinikum Essen, Hufelandstrasse 55, 45122 Essen, Germany. rainer_schulz@uni-essen.de
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Adhesion
Cell Membrane Permeability
Connexin 43 / metabolism*
Gap Junctions / metabolism*
Humans
Ion Channels / metabolism*
Ischemic Preconditioning, Myocardial*
Myocardial Reperfusion Injury / metabolism
Myocardium / metabolism*
Chemical
Reg. No./Substance:
0/Connexin 43; 0/Ion Channels

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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