Document Detail

Connexin 43 and ischemic preconditioning.
MedLine Citation:
PMID:  15094353     Owner:  NLM     Status:  MEDLINE    
Connexin 43 (Cx43) is the essential protein to form hemichannels and gap junctions in the myocardium. The phosphorylation status of Cx43 which is regulated by a variety of protein kinases and phosphatases determines hemichannel and/or gap junction conductance and permeability. Gap junctions are involved in cell-cell coupling while hemichannels contribute to cardiomyocyte volume regulation. Cx43-formed channels are involved in ischemia/reperfusion injury, since blockade of a large portion of Cx43-formed channels attenuates ischemic hypercontracture, infarct development and post myocardial infarction remodeling. Ischemic preconditioning's protection also depends on functional Cx43-formed channels, since uncoupling of channels or genetic Cx43 deficiency abolishes infarct size reduction by ischemic preconditioning. The exact underlying mechanism(s) how Cx43 mediates protection remain to be established.
Rainer Schulz; Gerd Heusch
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Cardiovascular research     Volume:  62     ISSN:  0008-6363     ISO Abbreviation:  Cardiovasc. Res.     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-04-19     Completed Date:  2004-09-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0077427     Medline TA:  Cardiovasc Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  335-44     Citation Subset:  IM    
Institut für Pathophysiologie, Zentrum für Innere Medizin, Universitätsklinikum Essen, Hufelandstrasse 55, 45122 Essen, Germany.
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MeSH Terms
Cell Adhesion
Cell Membrane Permeability
Connexin 43 / metabolism*
Gap Junctions / metabolism*
Ion Channels / metabolism*
Ischemic Preconditioning, Myocardial*
Myocardial Reperfusion Injury / metabolism
Myocardium / metabolism*
Reg. No./Substance:
0/Connexin 43; 0/Ion Channels

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