Document Detail

Connexin 43 expression promotes malignancy of HuH7 hepatocellular carcinoma cells via the inhibition of cell-cell communication.
MedLine Citation:
PMID:  17275998     Owner:  NLM     Status:  MEDLINE    
In normal liver, Connexin (Cx) 43 is not detected, but up-regulated in some liver cancers. We herein investigated the role of Cx43 in hepatoma cell carcinogenesis. Cx43-silenced HuH7 cells using shRNA showed lower growth and higher differentiation, and Cx43-overexpressing cells exhibited rapid growth and low differentiation. Unexpectedly, gap junctional intercellular communication (GJIC) was inversely correlated with Cx43 levels. Furthermore, the expression level and promoter activity of Cx32 was negatively regulated by the expression of Cx43. From these data, Cx43 expression may be in part responsible for the malignancy of hepatoma cells through a decrease in GJIC composed of Cx32.
Dan Zhang; Makoto Kaneda; Ken-Ichi Nakahama; Shigeki Arii; Ikuo Morita
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-02-02
Journal Detail:
Title:  Cancer letters     Volume:  252     ISSN:  0304-3835     ISO Abbreviation:  Cancer Lett.     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-05-30     Completed Date:  2007-10-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7600053     Medline TA:  Cancer Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  208-15     Citation Subset:  IM    
Department of Cellular Physiological Chemistry, Tokyo Medical and Dental University 1-5-45, Yushima, Bunkyo-ku, Tokyo, Japan.
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MeSH Terms
Base Sequence
Blotting, Western
Carcinoma, Hepatocellular / metabolism*,  pathology
Cell Communication*
Cell Line, Tumor
Cell Proliferation
Connexin 43 / metabolism*
Connexins / genetics
DNA Primers
Gap Junctions / metabolism
Liver Neoplasms / metabolism*,  pathology
Transcription, Genetic
Reg. No./Substance:
0/Connexin 43; 0/Connexins; 0/DNA Primers; 0/connexin 32

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