| Connexin 43 expression promotes malignancy of HuH7 hepatocellular carcinoma cells via the inhibition of cell-cell communication. | |
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MedLine Citation:
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PMID: 17275998 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In normal liver, Connexin (Cx) 43 is not detected, but up-regulated in some liver cancers. We herein investigated the role of Cx43 in hepatoma cell carcinogenesis. Cx43-silenced HuH7 cells using shRNA showed lower growth and higher differentiation, and Cx43-overexpressing cells exhibited rapid growth and low differentiation. Unexpectedly, gap junctional intercellular communication (GJIC) was inversely correlated with Cx43 levels. Furthermore, the expression level and promoter activity of Cx32 was negatively regulated by the expression of Cx43. From these data, Cx43 expression may be in part responsible for the malignancy of hepatoma cells through a decrease in GJIC composed of Cx32. |
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Authors:
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Dan Zhang; Makoto Kaneda; Ken-Ichi Nakahama; Shigeki Arii; Ikuo Morita |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-02-02 |
Journal Detail:
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Title: Cancer letters Volume: 252 ISSN: 0304-3835 ISO Abbreviation: Cancer Lett. Publication Date: 2007 Jul |
Date Detail:
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Created Date: 2007-05-30 Completed Date: 2007-10-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7600053 Medline TA: Cancer Lett Country: Ireland |
Other Details:
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Languages: eng Pagination: 208-15 Citation Subset: IM |
Affiliation:
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Department of Cellular Physiological Chemistry, Tokyo Medical and Dental University 1-5-45, Yushima, Bunkyo-ku, Tokyo, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Base Sequence Blotting, Western Carcinoma, Hepatocellular / metabolism*, pathology Cell Communication* Cell Line, Tumor Cell Proliferation Connexin 43 / metabolism* Connexins / genetics DNA Primers Gap Junctions / metabolism Humans Liver Neoplasms / metabolism*, pathology Transcription, Genetic |
| Chemical | |
Reg. No./Substance:
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0/Connexin 43; 0/Connexins; 0/DNA Primers; 0/connexin 32 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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