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Connectivity of the amygdala, piriform, and orbitofrontal cortex during olfactory stimulation: a functional MRI study.
MedLine Citation:
PMID:  23381349     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The majority of existing functional MRI studies on olfactory perception have addressed the relationship between stimulus features and the intensity of activity in separate regions considered in isolation. However, anatomical studies as well as neurophysiological recordings in rats and insects suggest that odor features may also be represented in a sparse manner through the simultaneous activity of multiple cortical areas interacting as a network. Here, we aimed to map the interdependence of neural activity among regions of the human brain, representing functional connectivity, during passive smelling. Seventeen healthy participants were scanned while performing a blocked-design task alternating exposure to two unpleasant odorants and breathing fresh air. High efferent connectivity was detected for the piriform cortex and the amygdala bilaterally. By contrast, the medial orbitofrontal cortex was characterized by high afferent connectivity, notably in the absence of an overall change in the intensity of hemodynamic activity during olfactory stimulation. Our results suggest that, even in the context of an elementary task, information on olfactory stimuli is scattered by the amygdala and piriform cortex onto an anatomically sparse representation and then gathered and integrated in the medial orbitofrontal cortex.
Authors:
Anna Nigri; Stefania Ferraro; Ludovico D'Incerti; Hugo D Critchley; Maria Grazia Bruzzone; Ludovico Minati
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neuroreport     Volume:  24     ISSN:  1473-558X     ISO Abbreviation:  Neuroreport     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-05     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9100935     Medline TA:  Neuroreport     Country:  England    
Other Details:
Languages:  eng     Pagination:  171-5     Citation Subset:  IM    
Affiliation:
aNeuroradiology Unit bScientific Department, Besta Neurological Institute, Milan, Italy Departments of cPsychiatry dNeurology, Brighton and Sussex Medical School eSackler Centre for Consciousness Science, University of Sussex, Falmer fSussex Partnership NHS Foundation Trust, Brighton, UK.
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