Document Detail

Connectivity of the amygdala, piriform, and orbitofrontal cortex during olfactory stimulation: a functional MRI study.
MedLine Citation:
PMID:  23381349     Owner:  NLM     Status:  MEDLINE    
The majority of existing functional MRI studies on olfactory perception have addressed the relationship between stimulus features and the intensity of activity in separate regions considered in isolation. However, anatomical studies as well as neurophysiological recordings in rats and insects suggest that odor features may also be represented in a sparse manner through the simultaneous activity of multiple cortical areas interacting as a network. Here, we aimed to map the interdependence of neural activity among regions of the human brain, representing functional connectivity, during passive smelling. Seventeen healthy participants were scanned while performing a blocked-design task alternating exposure to two unpleasant odorants and breathing fresh air. High efferent connectivity was detected for the piriform cortex and the amygdala bilaterally. By contrast, the medial orbitofrontal cortex was characterized by high afferent connectivity, notably in the absence of an overall change in the intensity of hemodynamic activity during olfactory stimulation. Our results suggest that, even in the context of an elementary task, information on olfactory stimuli is scattered by the amygdala and piriform cortex onto an anatomically sparse representation and then gathered and integrated in the medial orbitofrontal cortex.
Anna Nigri; Stefania Ferraro; Ludovico D'Incerti; Hugo D Critchley; Maria Grazia Bruzzone; Ludovico Minati
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroreport     Volume:  24     ISSN:  1473-558X     ISO Abbreviation:  Neuroreport     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-05     Completed Date:  2013-07-29     Revised Date:  2014-09-23    
Medline Journal Info:
Nlm Unique ID:  9100935     Medline TA:  Neuroreport     Country:  England    
Other Details:
Languages:  eng     Pagination:  171-5     Citation Subset:  IM    
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MeSH Terms
Amygdala / anatomy & histology,  physiology
Brain Mapping*
Cerebral Cortex / anatomy & histology*,  physiology
Frontal Lobe / anatomy & histology,  physiology
Image Interpretation, Computer-Assisted
Magnetic Resonance Imaging
Middle Aged
Neural Pathways / anatomy & histology*,  physiology
Olfactory Pathways / physiology
Olfactory Perception / physiology*
Pyriform Sinus / anatomy & histology,  physiology
Young Adult
Erratum In:
Neuroreport. 2014 May 28;25(8):633

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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