Document Detail


Connectivity-Based Functional Analysis of Dopamine Release in the Striatum Using Diffusion-Weighted MRI and Positron Emission Tomography.
MedLine Citation:
PMID:  23283687     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The striatum acts in conjunction with the cortex to control and execute functions that are impaired by abnormal dopamine neurotransmission in disorders such as Parkinson's and schizophrenia. To date, in vivo quantification of striatal dopamine has been restricted to structure-based striatal subdivisions. Here, we present a multimodal imaging approach that quantifies the endogenous dopamine release following the administration of d-amphetamine in the functional subdivisions of the striatum of healthy humans with [(11)C]PHNO and [(11)C]Raclopride positron emission tomography ligands. Using connectivity-based (CB) parcellation, we subdivided the striatum into functional subregions based on striato-cortical anatomical connectivity information derived from diffusion magnetic resonance imaging (MRI) and probabilistic tractography. Our parcellation showed that the functional organization of the striatum was spatially coherent across individuals, congruent with primate data and previous diffusion MRI studies, with distinctive and overlapping networks. d-amphetamine induced the highest dopamine release in the limbic followed by the sensory, motor, and executive areas. The data suggest that the relative regional proportions of D2-like receptors are unlikely to be responsible for this regional dopamine release pattern. Notably, the homogeneity of dopamine release was significantly higher within the CB functional subdivisions in comparison with the structural subdivisions. These results support an association between local levels of dopamine release and cortical connectivity fingerprints.
Authors:
Andri C Tziortzi; Suzanne N Haber; Graham E Searle; Charalampos Tsoumpas; Christopher J Long; Paul Shotbolt; Gwenaelle Douaud; Saad Jbabdi; Timothy E J Behrens; Eugenii A Rabiner; Mark Jenkinson; Roger N Gunn
Related Documents :
2701037 - Magnetic resonance and computed tomographic image-directed stereotaxy for animal research.
7624107 - Morphology-oriented analysis of cerebral spet using matched magnetic resonance images.
21637057 - F-18 fdg pet for evaluation of bone marrow involvement in non-hodgkin lymphoma: a meta-...
12548367 - Anatomo-clinical correlation of intraoperative stimulation-induced side-effects during ...
453647 - Assessment of a technique for scintigraphic monitoring of pulmonary aspiration of gastr...
7396117 - Topography of the lumbar epidural space. a study in cadavers using injected polyester r...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-2
Journal Detail:
Title:  Cerebral cortex (New York, N.Y. : 1991)     Volume:  -     ISSN:  1460-2199     ISO Abbreviation:  Cereb. Cortex     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9110718     Medline TA:  Cereb Cortex     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
FMRIB Centre, Nuffield Department of Clinical Neurosciences.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Zbtb20 Defines a Hippocampal Neuronal Identity Through Direct Repression of Genes That Control Proje...
Next Document:  Common Variants in Psychiatric Risk Genes Predict Brain Structure at Birth.