| Connective tissue disorders in patients with spontaneous intracranial hypotension. | |
| | |
MedLine Citation:
|
PMID: 21220378 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Objective: Spontaneous intracranial hypotension (SIH) is caused by spinal cerebrospinal fluid (CSF) leakage. An underlying connective tissue disorder has been hypothesized to cause dural weakness and predisposition to CSF leak. We conducted a case-controlled study to investigate the role of connective tissue disorders in SIH patients. Methods: We recruited 55 consecutive SIH patients (38 F, 17 M; mean age, 40.8 ± 9.8 years) and 55 age- and sex-matched control individuals (mean age, 38.0 ± 8.9 years) for this study. The connective tissue disorders were evaluated by: (i) Beighton hypermobility scores and revised diagnostic criteria for benign joint hypermobility syndrome; (ii) skin and skeletal manifestations of Ehlers-Danlos syndrome (EDS); and (iii) skeletal features of Marfan syndrome. Results: The frequencies of joint hypermobility according to Beighton scores >4/9 (SIH 23.6% vs controls 16.4%, P = 0.48) and revised benign joint hypermobility syndrome criteria (SIH 23.6% vs controls 34.5%, P = 0.29) did not differ between SIH patients and controls. Sixteen patients and 16 controls had one or more skin features of EDS (P = 1.0). Nine SIH patients (16.4%) demonstrated the skeletal features of Marfan syndrome; this frequency did not differ from that of the control group (9.1%; P = 0.262). Only dolichostenomelia (disproportionately long limbs) was more prominent in SIH patients than in controls (34.5% vs 9.1%; P = 0.002). Conclusion: Compared with Western studies, the frequencies of connective tissue disorders were higher in our SIH patients. However, these frequencies did not differ between SIH patients and control individuals, except for dolichostenomelia. |
| | |
Authors:
|
Fang-Chun Liu; Jong-Ling Fuh; Yen-Feng Wang; Shuu-Jiun Wang |
Related Documents
:
|
519898 - Healthy female carriers of a gene for the alport syndrome: importance for genetic couns... 8385418 - Primitive neuroectodermal tumor of the chest wall in a patient with jeune's syndrome an... 8533848 - Phenotypic manifestations of branchio-oto-renal syndrome. 20734088 - Cystinosis: practical tools for diagnosis and treatment. 19830148 - Mesothelioma of the testis and nephrotic syndrome: a case report. 17351348 - Evaluating the association between congenital cystic adenomatoid malformation of the lu... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-1-10 |
Journal Detail:
|
Title: Cephalalgia : an international journal of headache Volume: - ISSN: 1468-2982 ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
|
Created Date: 2011-1-11 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8200710 Medline TA: Cephalalgia Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Suao Veterans Hospital and National Yang-Ming University School of Medicine, Taiwan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Intra-arterial application of nimodipine in reversible cerebral vasoconstriction syndrome: A diagnos...
Next Document: Risk factors for high-altitude headache in mountaineers.