| Connective tissue changes in the cervix during normal pregnancy and pregnancy complicated by cervical incompetence. | |
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MedLine Citation:
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PMID: 3353047 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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When postpartum cervical biopsy specimens were compared with biopsy specimens from nonpregnant women, they revealed a 12-fold decrease in mechanical strength, a 50% reduction in the concentrations of collagen and sulfated glycosaminoglycans, a 35% reduction in hyaluronic acid, an increase in collagen extractability, and a fivefold increase in collagenolytic activity. Primiparas with relatively high concentrations of collagen and hyaluronic acid had relatively long cervical dilatation times during established labor, suggesting a physiologic importance to these variables. This correlation was not found in multiparas, even though the mean values of the biochemical parameters tested were similar to those in primiparas. Second-trimester biopsy specimens taken from patients with cervical incompetence contained normal collagen concentrations, but relatively high collagen extractabilities and collagenolytic activities, exceeding normal postpartum values. A biopsy specimen that was tested biomechanically had a very low strength and very high extensibility. Most likely, these data reflect a high turnover of collagen in incompetent cervices, resulting in a high proportion of newly synthesized collagen with low biomechanical strength. |
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Authors:
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T Rechberger; N Uldbjerg; H Oxlund |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Obstetrics and gynecology Volume: 71 ISSN: 0029-7844 ISO Abbreviation: Obstet Gynecol Publication Date: 1988 Apr |
Date Detail:
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Created Date: 1988-05-12 Completed Date: 1988-05-12 Revised Date: 2009-10-26 |
Medline Journal Info:
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Nlm Unique ID: 0401101 Medline TA: Obstet Gynecol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 563-7 Citation Subset: AIM; IM |
Affiliation:
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Second Clinic of Operative Gynecology, Medical Academy of Lublin, Poland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Biomechanics Cervix Uteri / metabolism, physiology*, physiopathology Connective Tissue / metabolism, physiology*, physiopathology Female Humans Hyaluronic Acid / metabolism Hydroxyproline / metabolism Middle Aged Osmolar Concentration Pregnancy / metabolism, physiology* Uterine Cervical Incompetence / metabolism, physiopathology* |
| Chemical | |
Reg. No./Substance:
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51-35-4/Hydroxyproline; 9004-61-9/Hyaluronic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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