Document Detail

Connective tissue changes in the cervix during normal pregnancy and pregnancy complicated by cervical incompetence.
MedLine Citation:
PMID:  3353047     Owner:  NLM     Status:  MEDLINE    
When postpartum cervical biopsy specimens were compared with biopsy specimens from nonpregnant women, they revealed a 12-fold decrease in mechanical strength, a 50% reduction in the concentrations of collagen and sulfated glycosaminoglycans, a 35% reduction in hyaluronic acid, an increase in collagen extractability, and a fivefold increase in collagenolytic activity. Primiparas with relatively high concentrations of collagen and hyaluronic acid had relatively long cervical dilatation times during established labor, suggesting a physiologic importance to these variables. This correlation was not found in multiparas, even though the mean values of the biochemical parameters tested were similar to those in primiparas. Second-trimester biopsy specimens taken from patients with cervical incompetence contained normal collagen concentrations, but relatively high collagen extractabilities and collagenolytic activities, exceeding normal postpartum values. A biopsy specimen that was tested biomechanically had a very low strength and very high extensibility. Most likely, these data reflect a high turnover of collagen in incompetent cervices, resulting in a high proportion of newly synthesized collagen with low biomechanical strength.
T Rechberger; N Uldbjerg; H Oxlund
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  71     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  1988 Apr 
Date Detail:
Created Date:  1988-05-12     Completed Date:  1988-05-12     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  563-7     Citation Subset:  AIM; IM    
Second Clinic of Operative Gynecology, Medical Academy of Lublin, Poland.
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MeSH Terms
Cervix Uteri / metabolism,  physiology*,  physiopathology
Connective Tissue / metabolism,  physiology*,  physiopathology
Hyaluronic Acid / metabolism
Hydroxyproline / metabolism
Middle Aged
Osmolar Concentration
Pregnancy / metabolism,  physiology*
Uterine Cervical Incompetence / metabolism,  physiopathology*
Reg. No./Substance:
51-35-4/Hydroxyproline; 9004-61-9/Hyaluronic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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