| Connective tissue activation. XXX: Isoelectric point microheterogeneity of CTAP-III, a human platelet-derived growth factor. | |
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MedLine Citation:
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PMID: 3081909 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Connective tissue activating peptide (CTAP-III) is one of the growth factors found in the alpha granules of human platelets. This small cationic platelet protein shows several apparent isoelectric point variants after the preparative isoelectric focusing step in large scale preparations from multiple donors. Analytical isoelectricfocusing techniques under denaturing conditions, coupled with Western blotting and immunodetection, now show that CTAP-III prepared rapidly from single donors also has multiple isoelectric point variants, suggesting that this finding is more likely related to post-translational modification than preparative artifact or genetic polymorphism. |
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Authors:
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M S Green; P A Hossler; C W Castor |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) Volume: 181 ISSN: 0037-9727 ISO Abbreviation: Proc. Soc. Exp. Biol. Med. Publication Date: 1986 Apr |
Date Detail:
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Created Date: 1986-04-18 Completed Date: 1986-04-18 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7505892 Medline TA: Proc Soc Exp Biol Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 555-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Blood Platelets
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analysis Electrophoresis, Polyacrylamide Gel Growth Substances / analysis* Humans Immunodiffusion Isoelectric Point Peptides / analysis* Platelet-Derived Growth Factor / analysis* |
| Grant Support | |
ID/Acronym/Agency:
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AM-10728/AM/NIADDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Growth Substances; 0/Peptides; 0/Platelet-Derived Growth Factor; 69344-77-0/connective tissue-activating peptide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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