Document Detail

Connective tissue accumulation in the left coronary artery of young SHR.
MedLine Citation:
PMID:  6746084     Owner:  NLM     Status:  MEDLINE    
The left coronary artery of 21-, 28-, and 45-day-old spontaneously hypertensive rats and Wistar-Kyoto rats was analyzed morphometrically to evaluate the structural alterations of the vessel wall during the development of genetically determined hypertension. In 45-day-old rats, hypertension was associated with a significant expansion of the partial volume of collagen and ground substance (119%) within the arterial wall. This change exceeded the concurrent accumulation of elastin (77%) and smooth muscle cell mass (34%). The growth of the muscle compartment was also characterized by a marked increment of rough endoplasmic reticulum (103%). The increase in the mural concentration of fibrous proteins at this early age may be viewed as the initial adverse effect of hypertension on muscular arteries.
P Anversa; M Melissari; A Tardini; G Olivetti
Related Documents :
3943394 - Pulmonary vascular occlusion and fibrosing mediastinitis.
15747574 - Primary pulmonary arterial hypertension presenting as diffuse micronodules on ct.
6860554 - Electron microscopy of hypertensive pulmonary vascular disease.
19539354 - Natriuretic peptides in systemic sclerosis-related pulmonary arterial hypertension.
7076544 - The formation, septation and fate of the truncus arteriosus in man.
22614324 - Risk stratification and treatment strategy of pulmonary embolism.
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Hypertension     Volume:  6     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:    1984 Jul-Aug
Date Detail:
Created Date:  1984-09-14     Completed Date:  1984-09-14     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  526-9     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Blood Pressure
Connective Tissue / metabolism*
Coronary Vessels / metabolism*,  pathology,  ultrastructure
Hypertension / metabolism*,  pathology
Muscle, Smooth, Vascular / ultrastructure
Rats, Inbred Strains
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Regional hemodynamic effects of antihypertensive renomedullary lipids in conscious rats.
Next Document:  Neural and local control of arterioles in SHR.