Document Detail


Connective tissue accumulation in the left coronary artery of young SHR.
MedLine Citation:
PMID:  6746084     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The left coronary artery of 21-, 28-, and 45-day-old spontaneously hypertensive rats and Wistar-Kyoto rats was analyzed morphometrically to evaluate the structural alterations of the vessel wall during the development of genetically determined hypertension. In 45-day-old rats, hypertension was associated with a significant expansion of the partial volume of collagen and ground substance (119%) within the arterial wall. This change exceeded the concurrent accumulation of elastin (77%) and smooth muscle cell mass (34%). The growth of the muscle compartment was also characterized by a marked increment of rough endoplasmic reticulum (103%). The increase in the mural concentration of fibrous proteins at this early age may be viewed as the initial adverse effect of hypertension on muscular arteries.
Authors:
P Anversa; M Melissari; A Tardini; G Olivetti
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Hypertension     Volume:  6     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:    1984 Jul-Aug
Date Detail:
Created Date:  1984-09-14     Completed Date:  1984-09-14     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  526-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aging
Animals
Arteries
Blood Pressure
Connective Tissue / metabolism*
Coronary Vessels / metabolism*,  pathology,  ultrastructure
Hypertension / metabolism*,  pathology
Muscle, Smooth, Vascular / ultrastructure
Rats
Rats, Inbred Strains
Grant Support
ID/Acronym/Agency:
HL-24479/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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