| Connective tissue growth factor is associated with a stable atherosclerotic plaque phenotype and is involved in plaque stabilization after stroke. | |
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MedLine Citation:
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PMID: 20966418 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND PURPOSE: Carotid plaques remodel toward a more stable phenotype after stroke, but not after TIA. Connective tissue growth factor (CTGF) is involved in extracellular matrix production and is expressed in atherosclerotic plaques. We studied the role of CTGF in plaque remodeling after stroke and TIA. METHODS: Atherosclerotic plaques from carotid endarterectomy of asymptomatic patients (n = 16) and patients who experienced stroke (n = 15) or TIA (n = 33) were analyzed for CTGF levels, markers of plaque stability (collagen, smooth muscle cells, macrophage content, and lipid core), and levels of matrix metalloproteinase (MMP)-8, MMP-9, IL-4, IL-5, and IL-10. RESULTS: CTGF levels were higher in stroke patients compared to TIA patients. Plaques with a high level of CTGF revealed more collagen and smooth muscle cell content, whereas macrophage content and lipid core size were not different. The amount of CTGF was negatively associated with MMP-8 and MMP-9 activity and showed a positive correlation with the anti-inflammatory cytokines IL-4, IL-5, and IL-10. CONCLUSIONS: CTGF levels are associated with a more stable plaque phenotype. CTGF is increased in plaques after stroke compared to TIA, suggesting a role for CTGF in plaque stabilization after stroke. |
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Authors:
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Jan Willem Leeuwis; Tri Q Nguyen; Maarten G J Theunissen; Wouter Peeters; Roel Goldschmeding; Gerard Pasterkamp; Aryan Vink |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-10-21 |
Journal Detail:
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Title: Stroke; a journal of cerebral circulation Volume: 41 ISSN: 1524-4628 ISO Abbreviation: Stroke Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-30 Completed Date: 2010-12-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0235266 Medline TA: Stroke Country: United States |
Other Details:
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Languages: eng Pagination: 2979-81 Citation Subset: IM |
Affiliation:
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Department of Pathology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands. a.vink@umuctrecht.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Biological Markers Cell Proliferation Collagen / metabolism Connective Tissue Growth Factor / metabolism* Endarterectomy, Carotid Extracellular Matrix / metabolism Female Humans Interleukins / metabolism Male Matrix Metalloproteinases / metabolism Middle Aged Myocytes, Smooth Muscle / physiology Plaque, Atherosclerotic / metabolism*, pathology* Risk Factors Stroke / metabolism*, pathology* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Interleukins; 139568-91-5/Connective Tissue Growth Factor; 9007-34-5/Collagen; EC 3.4.24.-/Matrix Metalloproteinases |
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