Document Detail

Connecting white matter injury and thalamic atrophy in clinically isolated syndromes.
MedLine Citation:
PMID:  19394969     Owner:  NLM     Status:  MEDLINE    
Previous studies suggest that thalamic degeneration is prominent in multiple sclerosis (MS) and even in pre-MS patients presenting with a clinically isolated syndrome (CIS). However, the relationships between white matter lesions and deep grey matter loss are not well understood. We analyzed the association between white matter lesions and the thalami in CIS patients to determine if connectivity is an important determinant. We studied 24 CIS patients and 18 normal controls with anatomical and diffusion tensor (DTI) MRI images. DTI fiber tracking was used to create probabilistic templates of the thalamocortical white matter and to define white matter connecting lesions and thalami. DTI metrics in the lesions and normal-appearing white matter (NAWM) regions were compared between CIS and controls, and correlated with thalamic volume changes estimated by voxel-based morphometry. There was 10 times higher density of lesions in thalamocortical compared to other brain white matter. Increased diffusivities and decreased fractional anisotropies were measured in the thalamocortical NAWM of CIS patients compared to controls. A step-wise regression analysis demonstrated that thalamocortical lesion volume and the mean diffusivity in track regions connecting lesion and thalami were significantly correlated with thalamic volumes in patients (Rsq=0.66, p<0.001), a finding not observed in regions outside the thalamocortical white matter. These results provide compelling evidence for a direct relationship between white matter lesions and thalamic atrophy in CIS patients.
Roland G Henry; Mason Shieh; Bagrat Amirbekian; SungWon Chung; Darin T Okuda; Daniel Pelletier
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2009-04-23
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  282     ISSN:  1878-5883     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-06-08     Completed Date:  2009-08-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  61-6     Citation Subset:  IM    
Department of Radiology and Biomedical Imaging, University of California at San Francisco, USA.
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MeSH Terms
Cerebral Cortex / pathology*
Cohort Studies
Demyelinating Diseases / pathology*
Diffusion Magnetic Resonance Imaging / methods
Imaging, Three-Dimensional
Magnetic Resonance Imaging
Middle Aged
Nerve Fibers, Myelinated / pathology*
Neural Pathways / pathology
Organ Size
Regression Analysis
Thalamus / pathology*
Young Adult
Grant Support

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