Document Detail


Connecting the mechanisms of T-cell regulation: dendritic cells as the missing link.
MedLine Citation:
PMID:  20636819     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A variety of different molecular mechanisms have been proposed to explain the suppressive action of regulatory T cells, including the production of anti-inflammatory cytokines, negative costimulatory ligands, indoleamine 2,3-dioxygenase-mediated tryptophan catabolism, CD73-mediated adenosine generation, and downregulation of antigen-presenting cells. Until now it has been unclear how important each of these different mechanisms might be and how they are coordinated. In this review, we examine the hypothesis that it is the interaction between regulatory T cells and dendritic cells that creates a local microenvironment depleted of essential amino acids and rich in adenosine that leads to the amplification of a range of different tolerogenic signals. These signals are all eventually integrated by mammalian target of rapamycin inhibition, which enables the induction of new forkhead box protein 3-expressing Tregs. If correct, this provides a molecular explanation for the in vivo phenomena of linked suppression and infectious tolerance.
Authors:
Stephen P Cobbold; Elizabeth Adams; Kathleen F Nolan; Frederico S Regateiro; Herman Waldmann
Related Documents :
19869059 - Immunological relationships of cell constituents of pneumococcus : second paper.
19547119 - Real-time actin-cytoskeleton depolymerization detection in a single cell using optical ...
22445949 - Development and validation of an in vitro micronucleus assay platform in tk6 cells.
12361589 - Microtubules and microfilaments in cell morphogenesis in higher plants.
19907189 - T-lymphocytes and disease mechanisms in wegener's granulomatosis.
20739889 - T-cell immunotherapy for malignant glioma: toward a combined approach.
12777499 - Conditional expression of mycobacterium smegmatis ftsz, an essential cell division gene.
23300799 - P62/sqstm1-dependent autophagy of lewy body-like α-synuclein inclusions.
22262369 - Autophagy mediates survival of pancreatic tumour-initiating cells in a hypoxic microenv...
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Immunological reviews     Volume:  236     ISSN:  1600-065X     ISO Abbreviation:  Immunol. Rev.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-19     Completed Date:  2010-10-29     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  7702118     Medline TA:  Immunol Rev     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  203-18     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Antigen-Presenting Cells / immunology,  metabolism
Cell Communication / immunology*
Dendritic Cells / immunology*
Forkhead Transcription Factors / metabolism
Humans
Indoleamine-Pyrrole 2,3,-Dioxygenase / metabolism
Models, Immunological
Signal Transduction / immunology*
T-Lymphocytes, Regulatory / immunology*,  metabolism
Grant Support
ID/Acronym/Agency:
G1000215//Medical Research Council
Chemical
Reg. No./Substance:
0/Forkhead Transcription Factors; 0/Indoleamine-Pyrrole 2,3,-Dioxygenase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The metabolic life and times of a T-cell.
Next Document:  The PD-1 pathway in tolerance and autoimmunity.