| Connecting cell-cycle activation to neurodegeneration in Drosophila. | |
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MedLine Citation:
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PMID: 17141486 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Studies in cell-culture systems and in postmortem tissue from human disease have suggested a connection between cell-cycle activation and neurodegeneration. The fruit fly Drosophila melanogaster has recently emerged as a powerful model system in which to model neurodegenerative diseases. Here we review work in the fly that has begun to address some of the important questions regarding the relationship between cell-cycle activation and neurodegeneration in vivo, including recent data implicating cell-cycle activation as a downstream effector of tau-induced neurodegeneration. We suggest how powerful research tools in Drosophila might be utilized to approach fundamental questions that remain. |
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Authors:
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Vikram Khurana; Mel B Feany |
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Publication Detail:
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Type: Journal Article; Review Date: 2006-10-18 |
Journal Detail:
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Title: Biochimica et biophysica acta Volume: 1772 ISSN: 0006-3002 ISO Abbreviation: Biochim. Biophys. Acta Publication Date: 2007 Apr |
Date Detail:
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Created Date: 2007-03-19 Completed Date: 2007-04-26 Revised Date: 2011-05-27 |
Medline Journal Info:
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Nlm Unique ID: 0217513 Medline TA: Biochim Biophys Acta Country: Netherlands |
Other Details:
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Languages: eng Pagination: 446-56 Citation Subset: IM |
Affiliation:
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Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Harvard New Research Building Room 652, 77 Louis Pasteur Avenue, Boston, MA 02115, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Cycle / physiology* Cell Division Disease Models, Animal Drosophila / physiology* Nerve Degeneration / pathology* Neurons / cytology, pathology, physiology Signal Transduction Tauopathies / pathology |
| Grant Support | |
ID/Acronym/Agency:
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K08 AG000880-01/AG/NIA NIH HHS; K08 AG000880-02/AG/NIA NIH HHS; K08 AG000880-03/AG/NIA NIH HHS; K08 AG000880-04/AG/NIA NIH HHS; K08 AG000880-05/AG/NIA NIH HHS; P50 AG005134-210026/AG/NIA NIH HHS; P50 AG005134-220026/AG/NIA NIH HHS; P50 AG005134-230026/AG/NIA NIH HHS; R01 AG019790-01/AG/NIA NIH HHS; R01 AG019790-02/AG/NIA NIH HHS; R01 AG019790-03/AG/NIA NIH HHS; R01 AG019790-04/AG/NIA NIH HHS; R01 AG019790-05/AG/NIA NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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