Document Detail

Connecting cancer to the asymmetric division of stem cells.
MedLine Citation:
PMID:  16564003     Owner:  NLM     Status:  MEDLINE    
Two studies, one in this issue of Cell and the other in Developmental Cell show that the cell-fate determinant Brain Tumor (Brat) suppresses self-renewal in one of the daughter cells that arise from the asymmetric division of a neural stem cell. This work suggests a mechanism by which loss of polarity in stem cells may lead to tumorigenesis.
Andreas Wodarz; Cayetano Gonzalez
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Publication Detail:
Type:  Comment; Journal Article; Review    
Journal Detail:
Title:  Cell     Volume:  124     ISSN:  0092-8674     ISO Abbreviation:  Cell     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-03-27     Completed Date:  2006-05-10     Revised Date:  2008-10-16    
Medline Journal Info:
Nlm Unique ID:  0413066     Medline TA:  Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1121-3     Citation Subset:  IM    
Department of Stem Cell Biology, DFG Research Center for Molecular Physiology of the Brain (CMPB), University of Göttingen, Justus-von-Liebig-Weg 11, 37077 Göttingen, Germany.
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MeSH Terms
Cell Division* / genetics
DNA-Binding Proteins / physiology
Drosophila / embryology
Drosophila Proteins / physiology
Neoplasms / etiology*,  genetics,  pathology*
Nerve Tissue Proteins / physiology
Nuclear Proteins / physiology
Stem Cells / cytology*
Transcription Factors / physiology
Reg. No./Substance:
0/DNA-Binding Proteins; 0/Drosophila Proteins; 0/Nerve Tissue Proteins; 0/Nuclear Proteins; 0/Transcription Factors; 0/brat protein, Drosophila; 0/pros protein, Drosophila
Comment On:
Cell. 2006 Mar 24;124(6):1241-53   [PMID:  16564014 ]

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