| Connecting cancer to the asymmetric division of stem cells. | |
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MedLine Citation:
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PMID: 16564003 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Two studies, one in this issue of Cell and the other in Developmental Cell show that the cell-fate determinant Brain Tumor (Brat) suppresses self-renewal in one of the daughter cells that arise from the asymmetric division of a neural stem cell. This work suggests a mechanism by which loss of polarity in stem cells may lead to tumorigenesis. |
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Authors:
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Andreas Wodarz; Cayetano Gonzalez |
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Publication Detail:
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Type: Comment; Journal Article; Review |
Journal Detail:
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Title: Cell Volume: 124 ISSN: 0092-8674 ISO Abbreviation: Cell Publication Date: 2006 Mar |
Date Detail:
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Created Date: 2006-03-27 Completed Date: 2006-05-10 Revised Date: 2008-10-16 |
Medline Journal Info:
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Nlm Unique ID: 0413066 Medline TA: Cell Country: United States |
Other Details:
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Languages: eng Pagination: 1121-3 Citation Subset: IM |
Affiliation:
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Department of Stem Cell Biology, DFG Research Center for Molecular Physiology of the Brain (CMPB), University of Göttingen, Justus-von-Liebig-Weg 11, 37077 Göttingen, Germany. awodarz@gwdg.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Division* / genetics DNA-Binding Proteins / physiology Drosophila / embryology Drosophila Proteins / physiology Humans Neoplasms / etiology*, genetics, pathology* Nerve Tissue Proteins / physiology Nuclear Proteins / physiology Stem Cells / cytology* Transcription Factors / physiology |
| Chemical | |
Reg. No./Substance:
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0/DNA-Binding Proteins; 0/Drosophila Proteins; 0/Nerve Tissue Proteins; 0/Nuclear Proteins; 0/Transcription Factors; 0/brat protein, Drosophila; 0/pros protein, Drosophila |
| Comments/Corrections | |
Comment On:
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Cell. 2006 Mar 24;124(6):1241-53
[PMID:
16564014
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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