Document Detail

Connatal (fetal) hydrocephalus: an acquired pathology?
MedLine Citation:
PMID:  7758019     Owner:  NLM     Status:  MEDLINE    
We investigated the etiology of hydrocephalus present at birth, i.e. of fetal hydrocephalus. Both inherited and dysraphic major malformations are very rare. Intraventricular hemorrhages and viral infections during pregnancy are among the proposed etiologies; they are supported more by anatomical, physiopathological and experimental findings than by clinical evidence. Cases of fetal intraventricular hemorrhages cited in the literature are anecdotical, and the reports fail to identify maternal or fetal predisposing factors. The role of viruses in the etiology of connatal hydrocephalus has been postulated on the basis of epidemiological considerations in human pathology and of a considerable amount of experimental studies in animals. Investigations were generally focused on aqueduct ependyma, but research should also address other structures involved in the genesis of hydrocephalus (choroid plexus, extraventricular CSF pathways, including arachnoid villi). Furthermore, experimental evidence has emerged concerning a number of toxins and of drugs administered during pregnancy, which are thought to be involved in the genesis of hydrocephalus: once more, the conclusions reached in these experimental trials lend further credence to the human epidemiological data linking pregnancy disturbances with fetal hydrocephalus. Since most of these toxic agents are also thought to induce major malformations, we could assume the degree of their effect to depend on the embryonal stage affected: the earlier the action, the worse the malformation.
R Guiffrè; F S Pastore; S De Santis
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery     Volume:  11     ISSN:  0256-7040     ISO Abbreviation:  Childs Nerv Syst     Publication Date:  1995 Feb 
Date Detail:
Created Date:  1995-06-26     Completed Date:  1995-06-26     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8503227     Medline TA:  Childs Nerv Syst     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  97-101     Citation Subset:  IM    
Institute of Neurosurgery, University of Rome, Tor Vergata, Italy.
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MeSH Terms
Cerebral Hemorrhage / etiology,  pathology
Cerebral Ventricles / pathology
Gestational Age
Hydrocephalus / etiology*,  pathology
Infant, Newborn
Prenatal Exposure Delayed Effects*
Retrospective Studies
Risk Factors

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