Document Detail


Conjunctival transplantation. Autologous and homologous grafts.
MedLine Citation:
PMID:  3904687     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Autologous conjunctival transplants have been used successfully for restoration of damaged ocular surfaces. Homologous (allogeneic) conjunctival grafts have been explored less systematically. We developed a nonhuman primate model for comparison of autologous and homologous conjunctival transplantation in order to assess the clinical viability and immunopathologic characteristics of these grafts. Autologous or homologous grafts were performed in nine adult rhesus monkeys. Both autologous and homologous grafts were compared for clinical viability and immunopathologic change. Clinical results suggest that, although homologous grafts incited a greater inflammatory and scarring response, there was minimal graft shrinkage and a normal surface epithelium. Immunopathologic studies using laminin, bullous pemphigoid antigen, and fibronectin indicate that, despite the increased inflammatory response seen in homografts, the epithelial surface is normal. With our increasing ability to modulate the immune response, conjunctival homografts may play a role in restoration of the ocular surface.
Authors:
R A Weise; M J Mannis; D W Vastine; L S Fujikawa; A M Roth
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Archives of ophthalmology     Volume:  103     ISSN:  0003-9950     ISO Abbreviation:  Arch. Ophthalmol.     Publication Date:  1985 Nov 
Date Detail:
Created Date:  1985-11-26     Completed Date:  1985-11-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7706534     Medline TA:  Arch Ophthalmol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1736-40     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Autoantigens / analysis
Carrier Proteins*
Collagen*
Conjunctiva / immunology,  injuries,  pathology,  transplantation*
Cytoskeletal Proteins*
Epithelium / immunology,  pathology
Fibroblasts
Fibronectins / analysis
Fluorescent Antibody Technique
Graft Survival
Immunosuppression
Laminin / analysis
Macaca mulatta
Models, Biological
Nerve Tissue Proteins*
Non-Fibrillar Collagens*
Transplantation Immunology
Transplantation, Autologous
Transplantation, Homologous
Chemical
Reg. No./Substance:
0/Autoantigens; 0/Carrier Proteins; 0/Cytoskeletal Proteins; 0/Dst protein, mouse; 0/Fibronectins; 0/Laminin; 0/Nerve Tissue Proteins; 0/Non-Fibrillar Collagens; 0/collagen type XVII; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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