Document Detail

Conjunctival hypoxia in diabetes mellitus.
MedLine Citation:
PMID:  3759367     Owner:  NLM     Status:  MEDLINE    
A frequently cited theory for the pathogenesis of neovascularization in diabetic retinopathy is that retinal hypoxia and/or ischemia release a factor which stimulates neovascularization. To the authors' knowledge, there is no direct in vivo evidence in the human proving this theory. One hundred and twenty-two diabetic subjects were studied to see whether worsening retinopathy was associated with changes in conjunctival oxygen tension (pO2). Diabetics without retinopathy had a conjunctival pO2 which was similar to an age-matched normal population. Diabetics with only background retinopathy had a significantly lower conjunctival pO2 than those without retinopathy (P less than 0.01). Diabetics with proliferative retinopathy showed a conjunctival pO2 that was significantly lower than either of the first two groups (P less than 0.05). The lowest value of all was found in patients with rubeosis iridis. Duration of diabetes alone did not correlate significantly to conjunctival pO2. These findings support the hypoxic theory of diabetic neovascular retinopathy.
S J Isenberg; W E McRee; M S Jedrzynski
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Investigative ophthalmology & visual science     Volume:  27     ISSN:  0146-0404     ISO Abbreviation:  Invest. Ophthalmol. Vis. Sci.     Publication Date:  1986 Oct 
Date Detail:
Created Date:  1986-11-13     Completed Date:  1986-11-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7703701     Medline TA:  Invest Ophthalmol Vis Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1512-5     Citation Subset:  IM    
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MeSH Terms
Aged, 80 and over
Anoxia / etiology*
Conjunctival Diseases / etiology*
Diabetes Complications*
Diabetes Mellitus, Type 1 / complications
Diabetes Mellitus, Type 2 / complications
Diabetic Retinopathy / physiopathology
Middle Aged

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