Document Detail


Conjunctival hemorrhagic events associated with imatinib mesylate.
MedLine Citation:
PMID:  18192104     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Imatinib mesylate (IM) is used in the targeted therapy of chronic myelogenous leukemia and gastrointestinal stromal tumors. It is well tolerated and leads to no higher incidence of hemorrhagic events than other therapies. Of 87 patients we treated with IM for a minimum of 3 months, 10 patients (11%) developed unilateral or bilateral conjunctival hemorrhage (CH). No other hemorrhagic events were observed during follow-up, except for CH recurrence in 6 cases (7%). Because there was no other obvious reason for such a high incidence of CH, we hypothesize drug hypersensitivity or ocular irritation induced by IM treatment.
Authors:
Franca Radaelli; Claudia Vener; Francesco Ripamonti; Alessandra Iurlo; Mariangela Colombi; Andrea Artoni; Gianluigi Reda; Giorgio Lambertenghi Deliliers
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  International journal of hematology     Volume:  86     ISSN:  0925-5710     ISO Abbreviation:  Int. J. Hematol.     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2008-01-14     Completed Date:  2008-03-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9111627     Medline TA:  Int J Hematol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  390-3     Citation Subset:  IM    
Affiliation:
Ematologia II-Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Via Francesco Sforza 35, Milan, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Antineoplastic Agents / administration & dosage,  adverse effects*
Conjunctival Diseases / chemically induced*,  pathology
Drug Hypersensitivity / pathology
Female
Follow-Up Studies
Gastrointestinal Stromal Tumors / drug therapy,  pathology
Hemorrhage / chemically induced*,  pathology
Humans
Incidence
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / complications,  drug therapy,  pathology
Male
Middle Aged
Piperazines / administration & dosage,  adverse effects*
Pyrimidines / administration & dosage,  adverse effects*
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Piperazines; 0/Pyrimidines; 152459-95-5/imatinib

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