Document Detail

Conjunctival goblet cell densities in ocular surface disease.
MedLine Citation:
PMID:  6378156     Owner:  NLM     Status:  MEDLINE    
Goblet cell densities were determined in the eyes of normal subjects and in the eyes of patients with various ocular surface diseases using an impression cytological technique. For normal eyes goblet cell densities on the interpalpebral bulbar and inferior palpebral ocular surfaces were 443 (+/- 266 [+/- SD]) and 1,972 (+/- 862) cells millimeter, per square, respectively. All patients in the ocular surface disease groups had decreased goblet cell densities compared with subjects with normal eyes. Compared with normal eyes, eyes with keratoconjunctivitis sicca (KCS) demonstrated a 17% greater goblet cell loss on the interpalpebral bulbar compared with the inferior palpebral ocular surface, while eyes with blepharitis and secondary KCS demonstrated an 8% greater loss on the inferior palpebral surface compared with the interpalpebral bulbar ocular surface. Eyes with cicatricial ocular pemphigoid and Stevens-Johnson syndrome demonstrated greater than 95% goblet cell loss on both the interpalpebral bulbar and inferior palpebral ocular surfaces compared with normal eyes.
J D Nelson; J C Wright
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of ophthalmology     Volume:  102     ISSN:  0003-9950     ISO Abbreviation:  Arch. Ophthalmol.     Publication Date:  1984 Jul 
Date Detail:
Created Date:  1984-08-01     Completed Date:  1984-08-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7706534     Medline TA:  Arch Ophthalmol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1049-51     Citation Subset:  AIM; IM    
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MeSH Terms
Burns, Chemical / pathology
Conjunctiva / pathology*
Cytological Techniques
Eye Burns / chemically induced,  pathology
Eye Diseases / pathology*
Keratoconjunctivitis / pathology
Middle Aged
Pemphigoid, Benign Mucous Membrane / pathology
Sjogren's Syndrome / pathology
Stevens-Johnson Syndrome / pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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