Document Detail


Conjunctival deposits as the first sign of systemic sarcoidosis in a pediatric patient.
MedLine Citation:
PMID:  16496264     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: Sarcoidosis is an inflammatory disease of unknown cause, characterized by noncaseating granulomas. In this study, the authors present a sarcoidosis patient without systemic signs diagnosed by histopathologic analysis of conjunctival deposits. METHODS: A 10-year-old girl had bilateral, focal, multilobular, multiple pale yellow deposits in bulbar conjunctiva for a year. In the patient's biomicroscopic examination, numerous 0.50- to 2-mm diameter pale yellow deposits were determined in both bulbar conjunctivas. The patient had no other systemic or ocular complaints. A conjunctival biopsy was performed. RESULTS: The biopsy specimens showed noncaseating granulomas with prominent asteroid bodies. Serum angiotensin-converting enzyme levels were increased in the patient. Conjunctival deposits were the first manifestation of sarcoidosis in the patient and the diagnosis of sarcoidosis was confirmed with a conjunctival biopsy. CONCLUSIONS: To the authors' knowledge, this is the second study that reports a sarcoidosis patient with non-systemic involvement diagnosed after histopathologic analysis of conjunctival deposits.
Authors:
I Caça; K Unlü; H Büyükbayram; S Ari
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  European journal of ophthalmology     Volume:  16     ISSN:  1120-6721     ISO Abbreviation:  Eur J Ophthalmol     Publication Date:    2006 Jan-Feb
Date Detail:
Created Date:  2006-02-23     Completed Date:  2006-05-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9110772     Medline TA:  Eur J Ophthalmol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  168-70     Citation Subset:  IM    
Affiliation:
Department of Ophthalmology, Dicle University Faculty of Medicine, Diyarbakiyr, Turkey. ihsancaca@mynet.com
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MeSH Terms
Descriptor/Qualifier:
Biopsy
Child
Conjunctiva / pathology*
Conjunctival Diseases / diagnosis*,  enzymology
Female
Granuloma / pathology
Humans
Peptidyl-Dipeptidase A / blood
Sarcoidosis / diagnosis*
Chemical
Reg. No./Substance:
EC 3.4.15.1/Peptidyl-Dipeptidase A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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