Document Detail

[Conjunctival autologous transplantation using fibrin glue in primary pterygium].
MedLine Citation:
PMID:  20944939     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To assess the rate of recurrence and complications after primary pterygium removal with conjunctival autograft using fibrin tissue adhesive. Secondarily, to compare these results with a retrospective series that underwent the same surgery using sutures.
METHODS: A hundred and six eyes of 100 patients who underwent surgery with fibrin glue were prospectively studied, while 58 eyes of 51 patients who underwent surgery with sutures were retrospectively evaluated. Data included: age, gender, eye involved, location, grade and pterygium invasion and post-operative complications. Patients were followed for at least 5 months.
RESULTS: Among 106 eyes undergoing surgery with fibrin glue, 12 (11.3%) had recurrence, including 4 (3.8%) conjunctival and 8 (7.5%) corneal. Mean age was statistically inferior in the recurrence cases compared to others (mean of 34.6 vs. 43.7; P=0.033). The time for recurrence ranged from 1.6 to 13.1 months (mean of 4.4). Among the corneal recurrences, 2 eyes had invasion beyond the limbus of up to 0.5 mm and 6 eyes from 0.6 to 1.0 mm. No eye underwent reoperation. Other complications included: transitory granuloma formation in 3 cases, partial graft detachment or slippage in 3 and dellen in 1. In the suture group, 15 eyes (25.9%) had recurrence, including 8 conjunctival (13.8%) and 7 (12.1%) corneal. The time for recurrence ranged from 0.7 to 9.7 months (mean 4.5 months). The conjunctival recurrence rate was statistically inferior in the glue group compared to the suture (P=0.023), however no statistically significant difference was observed in relation to corneal recurrence (P=0.232).
CONCLUSION: The use of fibrin glue as an alternative to sutures in pterygium surgery was associated with good results and few complications. Despite a decrease in conjunctival recurrence rates, this technique does not appear to significantly decrease corneal recurrences.
Ramon Coral-Ghanem; Renan Ferreira Oliveira; Eduardo Furlanetto; Marcielle Abicalaffe Ghanem; Vinícius Coral Ghanem
Publication Detail:
Type:  Comparative Study; English Abstract; Journal Article    
Journal Detail:
Title:  Arquivos brasileiros de oftalmologia     Volume:  73     ISSN:  1678-2925     ISO Abbreviation:  Arq Bras Oftalmol     Publication Date:    2010 Jul-Aug
Date Detail:
Created Date:  2010-10-14     Completed Date:  2011-08-12     Revised Date:  2012-01-31    
Medline Journal Info:
Nlm Unique ID:  0400645     Medline TA:  Arq Bras Oftalmol     Country:  Brazil    
Other Details:
Languages:  por     Pagination:  350-3     Citation Subset:  IM    
Departamento de Oftalmologia, Faculdade de Medicina, Universidade de São Paulo - USP, São Paulo, SP, Brasil.
Vernacular Title:
Transplante autólogo de conjuntiva com uso de cola de fibrina em pterígios primários.
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MeSH Terms
Age Factors
Conjunctiva / transplantation*
Fibrin Tissue Adhesive / therapeutic use*
Follow-Up Studies
Middle Aged
Postoperative Complications*
Pterygium / surgery*
Retrospective Studies
Time Factors
Transplantation, Autologous / methods
Treatment Outcome
Reg. No./Substance:
0/Fibrin Tissue Adhesive

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