Document Detail


Conjunctival stromal tumor: report of 4 cases.
MedLine Citation:
PMID:  22200094     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To describe the clinical, histopathologic, immunohistochemical, and ultrastructural features of a case series of benign stromal tumors in the bulbar conjunctiva.
DESIGN: Observational case series.
PARTICIPANTS: Four patients with a conjunctival lesion that were classified histologically as low-grade stromal tumors consisting of spindle-shaped cells with occasional pseudonuclear inclusion and multinucleated cells in a partly myxoid matrix.
METHODS: Four cases of low-grade conjunctival stromal tumors were retrospectively identified in an ophthalmic pathology laboratory database. Patients' records were analyzed for demographic data, clinical appearance, and the postoperative course. Formalin-fixed, paraffin-embedded specimens were routinely processed and stained with hematoxylin and eosin and periodic acid Schiff. Immunohistochemical stains for vimentin, S100, CD34, smooth muscle actin (SMA), CD68, and factor XIIIa were performed. Transmission electron microscopy (TEM) was performed on 3 of the cases.
MAIN OUTCOME MEASURES: Histopathologic evaluation (including immunostains and TEM) and clinical correlation.
RESULTS: All 4 tumors occurred in the bulbar conjunctiva of patients between 41 to 53 years of age. None of the patients developed recurrence after excisional biopsy. Histologically, all tumors exhibited spindle-shaped cells with pseudonuclear inclusions and occasional multinuclear cells. Mitotic figures were not observed. The stroma seemed to be myxoid to collagenous. Immunohistochemical stains were positive for CD34, vimentin, and focally for CD68, but were negative for S100 and SMA.
CONCLUSIONS: We propose to classify these benign lesions, which share distinct histopathologic features, as "conjunctival stromal tumors." A reactive/inflammatory component needs to be considered in the pathogenesis of this lesion.
Authors:
Martina C Herwig; Jill R Wells; Hans E Grossniklaus
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-12-24
Journal Detail:
Title:  Ophthalmology     Volume:  119     ISSN:  1549-4713     ISO Abbreviation:  Ophthalmology     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-04-04     Completed Date:  2012-05-17     Revised Date:  2014-09-24    
Medline Journal Info:
Nlm Unique ID:  7802443     Medline TA:  Ophthalmology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  682-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Actins / analysis
Adult
Antigens, CD / analysis
Antigens, CD34 / analysis
Antigens, Differentiation, Myelomonocytic / analysis
Conjunctival Neoplasms / chemistry,  pathology*,  surgery
Female
Humans
Immunoenzyme Techniques
Male
Mesenchymal Stromal Cells / chemistry,  pathology*
Middle Aged
Neoplasm Proteins / analysis
Retrospective Studies
S100 Proteins / analysis
Solitary Fibrous Tumors / chemistry,  pathology*,  surgery
Tumor Markers, Biological / analysis
Vimentin / analysis
Grant Support
ID/Acronym/Agency:
P30 EY006360/EY/NEI NIH HHS; P30EY06360/EY/NEI NIH HHS; T32 EY007092/EY/NEI NIH HHS; T32 EY007092-26/EY/NEI NIH HHS
Chemical
Reg. No./Substance:
0/ACTA2 protein, human; 0/Actins; 0/Antigens, CD; 0/Antigens, CD34; 0/Antigens, Differentiation, Myelomonocytic; 0/CD68 antigen, human; 0/Neoplasm Proteins; 0/S100 Proteins; 0/Tumor Markers, Biological; 0/Vimentin
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