| Conjugation of organic pollutants in aquatic species. | |
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MedLine Citation:
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PMID: 3297669 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Aquatic organisms can take up organic pollutants from their environment and subsequently excrete the pollutant or its biotransformation products (metabolites). Phase II (conjugation) biotransformation products are almost always less toxic than the unmetabolized organic pollutant. For many organic pollutants, the extent to which conjugates are formed is extremely important in determining the rate of excretion of the pollutant. This is because most conjugates (glycosides, sulfates, amino acid conjugates, mercapturic acids) are organic anions which are readily water-soluble and are rapidly excreted by fish (and probably higher invertebrates) by a combination of glomerular filtration and tubular transport. In this paper, each major conjugation pathway is discussed with respect to what is known about its occurrence in fish and aquatic invertebrates, both from in vivo and in vitro data. Although limited data are available, this paper also considers what is known about how each conjugation reaction affects the toxicity and potential for renal and biliary excretion of organic xenobiotic substrates. |
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Authors:
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M O James |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Environmental health perspectives Volume: 71 ISSN: 0091-6765 ISO Abbreviation: Environ. Health Perspect. Publication Date: 1987 Apr |
Date Detail:
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Created Date: 1987-07-28 Completed Date: 1987-07-28 Revised Date: 2010-09-09 |
Medline Journal Info:
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Nlm Unique ID: 0330411 Medline TA: Environ Health Perspect Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 97-103 Citation Subset: IM |
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biotransformation Fishes / metabolism* Sea Urchins / metabolism Water Pollutants / analysis* Water Pollutants, Chemical / analysis* |
| Chemical | |
Reg. No./Substance:
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0/Water Pollutants; 0/Water Pollutants, Chemical |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
| Full Text | |
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Journal Information Journal ID (nlm-ta): Environ Health Perspect ISSN: 0091-6765 |
Article Information Download PDF  Print publication date: Month: 4 Year: 1987 Volume: 71First Page: 97 Last Page: 103 ID: 1474345 PubMed Id: 3297669 |
| Conjugation of organic pollutants in aquatic species. | |
| M O James | |
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