Document Detail


Conjugation is essential for the anticholestatic effect of NorUrsodeoxycholic acid in taurolithocholic acid-induced cholestasis in rat liver.
MedLine Citation:
PMID:  21038414     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CONCLUSION: Conjugation is essential for the anticholestatic effect of norUDCA in a model of hepatocellular cholestasis. Combined therapy with UDCA and norUDCA may be superior to UDCA or norUDCA monotherapy in biliary disorders in which hepatocyte as well as cholangiocyte dysfunction contribute to disease progression.
Authors:
Gerald U Denk; Silvia Maitz; Ralf Wimmer; Christian Rust; Pietro Invernizzi; Sacha Ferdinandusse; Wim Kulik; Andrea Fuchsbichler; Peter Fickert; Michael Trauner; Alan F Hofmann; Ulrich Beuers
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  52     ISSN:  1527-3350     ISO Abbreviation:  Hepatology     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-01     Completed Date:  2010-11-24     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1758-68     Citation Subset:  IM    
Affiliation:
Department of Medicine II, Klinikum Großhadern, University of Munich, Munich, Germany.
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MeSH Terms
Descriptor/Qualifier:
Animals
Apoptosis / drug effects
Bile / secretion
Bile Acids and Salts / metabolism
Carcinoma, Hepatocellular / pathology
Cholangitis / drug therapy
Cholestasis / chemically induced*
Chromatography, Gas
Hepatoblastoma / pathology
Humans
Liver / drug effects,  metabolism
Liver Diseases / etiology*
Liver Neoplasms / pathology
Male
Mice
Rats
Rats, Sprague-Dawley
Taurine / metabolism
Taurolithocholic Acid / adverse effects*
Ursodeoxycholic Acid / therapeutic use
Chemical
Reg. No./Substance:
0/Bile Acids and Salts; 107-35-7/Taurine; 128-13-2/Ursodeoxycholic Acid; 516-90-5/Taurolithocholic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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