Document Detail

Conjugated linoleic acid supplementation in humans--metabolic effects.
MedLine Citation:
PMID:  11592727     Owner:  NLM     Status:  MEDLINE    
Supplementation with conjugated linoleic acid (CLA) induces a number of physiological effects in experimental animals, including reduced body fat content, decreased aortic lipid deposition, and improved serum lipid profile. Controlled trials on the effects of CLA in humans have hitherto been scarce. The aim of this study was to evaluate the effects of supplementation with CLA in healthy humans on anthropometric and metabolic variables and on the fatty acid composition of serum lipids and thrombocytes. Fifty-three healthy men and women, aged 23-63 yr, were randomly assigned to supplementation with CLA (4.2 g/d) or the same amount of olive oil during 12 wk in a double-blind fashion. The proportion of body fat decreased (-3.8%, P< 0.001) in the CLA-treated group, with a significant difference from the control group (P = 0.050). Body weight, body mass index, and sagittal abdominal diameter were unchanged. There were no major differences between the groups in serum lipoproteins, nonesterified fatty acids, plasma insulin, blood glucose, or plasminogen activator inhibitor 1 (PAI-1). In the CLA group the proportions of stearic, docosatetraenoic, and docosapentaenoic acids increased in serum lipids and thrombocytes, while proportions of palmitic, oleic, and dihomo-gamma-linolenic acids decreased, causing a decrease of the estimated delta-6 and delta-9 and an increase in the delta-5 desaturase activities. These results suggest that supplementation with CLA may reduce the proportion of body fat in humans and that CLA affects fatty acid metabolism. No effects on body weight, serum lipids, glucose metabolism, or PAI-1 were seen.
A Smedman; B Vessby
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Lipids     Volume:  36     ISSN:  0024-4201     ISO Abbreviation:  Lipids     Publication Date:  2001 Aug 
Date Detail:
Created Date:  2001-10-10     Completed Date:  2002-03-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0060450     Medline TA:  Lipids     Country:  United States    
Other Details:
Languages:  eng     Pagination:  773-81     Citation Subset:  IM    
Department of Public Health and Caring Sciences/Geriatrics, Uppsala University, Sweden.
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MeSH Terms
Apolipoproteins / blood
Blood Glucose / analysis
Blood Platelets / drug effects,  metabolism*
Body Composition / drug effects*
Body Weight / drug effects
Dietary Supplements*
Double-Blind Method
Fatty Acids / analysis
Linoleic Acid / pharmacology*
Lipid Metabolism*
Lipid Peroxidation / drug effects
Lipids / analysis
Middle Aged
Reg. No./Substance:
0/Apolipoproteins; 0/Blood Glucose; 0/Fatty Acids; 0/Lipids; 2197-37-7/Linoleic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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