Document Detail

Conjugated linoleic acid prevents cell growth and cytokine production induced by TPA in human keratinocytes NCTC 2544.
MedLine Citation:
PMID:  19540663     Owner:  NLM     Status:  MEDLINE    
Conjugated linoleic acid (CLA) is reported to have anti-cancer activity, based on animal and in vitro studies. Since it has been suggested that CLA anti-carcinogenic effect stems from its anti-inflammatory properties, this study investigated whether CLA can prevent cell proliferation induced by TPA in human keratinocytes NCTC 2544 contemporary to inhibition of inflammation. Results obtained showed that CLA prevents increased cell proliferation and production of pro-inflammatory molecules determined by TPA, being this effect due to modulation of PPARs and NFkB activity. The involvement of PPARalpha in CLA effect was demonstrated by adding to the cells an antagonist of PPARalpha.
Germana Martinasso; Silvia Saracino; Marina Maggiora; Manuela Oraldi; Rosa A Canuto; Giuliana Muzio
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-06-21
Journal Detail:
Title:  Cancer letters     Volume:  287     ISSN:  1872-7980     ISO Abbreviation:  Cancer Lett.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-02-01     Completed Date:  2010-02-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7600053     Medline TA:  Cancer Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  62-6     Citation Subset:  IM    
Copyright Information:
Copyright 2009 Elsevier Ireland Ltd. All rights reserved.
Dipartimento di Medicina ed Oncologia Sperimentale, Universit? di Torino, Corso Raffaello 30, 10125 Torino, Italy.
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MeSH Terms
Cell Proliferation / drug effects
Cells, Cultured
Cytokines / biosynthesis*
DNA / metabolism
Keratinocytes / drug effects*
Linoleic Acids, Conjugated / pharmacology*
NF-kappa B / metabolism
PPAR alpha / antagonists & inhibitors,  physiology
PPAR-beta / physiology
Tetradecanoylphorbol Acetate / toxicity*
Reg. No./Substance:
0/Cytokines; 0/Linoleic Acids, Conjugated; 0/NF-kappa B; 0/PPAR alpha; 0/PPAR-beta; 16561-29-8/Tetradecanoylphorbol Acetate; 9007-49-2/DNA

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