Document Detail

Conjugated linoleic acid-induced fatty liver can be attenuated by combination with docosahexaenoic acid in C57BL/6N mice.
MedLine Citation:
PMID:  16302788     Owner:  NLM     Status:  MEDLINE    
We investigated the effect of dietary combination of conjugated linoleic acid (CLA) and docosahexaenoic acid (DHA) to attenuate CLA-induced fatty liver in C57BL/6N mice. Mice were fed semisynthetic diets that contained either 6% high linoleic safflower oil (HL-SAF), 4% HL-SAF + 2% CLA, or 3.5% HL-SAF + 2% CLA + 0.5% DHA for 4 weeks. This 4 week feeding of CLA showed hepatic lipid accumulation concomitant with the decrease in adipose tissue weight in mice. However, 0.5% supplementation of DHA to the CLA diet could alleviate fatty liver without decreasing the antiobesity effect of CLA. The CLA diet promoted fatty acid synthesis in the liver, but DHA supplementation significantly attenuated the increase in enzyme activity induced by CLA. On the other hand, serum adipocytokines, leptin and adiponectin, were drastically decreased by CLA feeding, and DHA supplementation did not affect those levels. These results show that DHA supplementation to the CLA diet can attenuate CLA-induced fatty liver through the reduction of hepatic fatty acid synthesis without affecting adipocytokine production in C57BL/6N mice.
Teruyoshi Yanagita; Yu-Ming Wang; Koji Nagao; Yoko Ujino; Nao Inoue
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of agricultural and food chemistry     Volume:  53     ISSN:  0021-8561     ISO Abbreviation:  J. Agric. Food Chem.     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-11-23     Completed Date:  2006-02-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0374755     Medline TA:  J Agric Food Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  9629-33     Citation Subset:  IM    
Department of Applied Biological Sciences, Saga University, Saga 840-8502, Japan.
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MeSH Terms
Dietary Fats / administration & dosage*
Docosahexaenoic Acids / administration & dosage*
Fatty Liver / chemically induced*,  prevention & control*
Linoleic Acids, Conjugated / administration & dosage*,  toxicity*
Lipids / analysis,  blood
Liver / chemistry
Mice, Inbred C57BL
RNA, Messenger / analysis
Weight Gain / drug effects
Reg. No./Substance:
0/Dietary Fats; 0/Linoleic Acids, Conjugated; 0/Lipids; 0/RNA, Messenger; 25167-62-8/Docosahexaenoic Acids

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