Document Detail

Conjugated linoleic acid: a functional food?
MedLine Citation:
PMID:  14611723     Owner:  NLM     Status:  MEDLINE    
Scientific interest in conjugated linoleic acid (CLA) started in 1987 when Michael Pariza's team of Wisconsin University observed its inhibitory effects on chemically induced skin tumors in mice. Numerous studies have since examined CLA's role in cancer, immune function, oxidative stress, atherosclerosis, lipid and fatty acids metabolism, bone formation and composition, obesity, and diabetes. Still it's not clear yet either through which mechanisms CLA produces its numerous metabolic effects. We now know that CLA contents in cow milk fat can be enriched through dry fractionation, but this knowledge doesn't allow sufficient certainty to qualify this nutrient, as a functional food, capable of increasing well being and reducing the risk of disease.
N D'Orazio; C Ficoneri; G Riccioni; P Conti; T C Theoharides; M R Bollea
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  International journal of immunopathology and pharmacology     Volume:  16     ISSN:  0394-6320     ISO Abbreviation:  Int J Immunopathol Pharmacol     Publication Date:    2003 Sep-Dec
Date Detail:
Created Date:  2003-11-12     Completed Date:  2004-01-29     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8911335     Medline TA:  Int J Immunopathol Pharmacol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  215-20     Citation Subset:  IM    
Unit of Human Nutrition, Dept Biomedical Sciences, Chieti University, Chieti, Italy.
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MeSH Terms
Dietary Fats / administration & dosage,  isolation & purification,  metabolism,  therapeutic use
Food Analysis
Linoleic Acids, Conjugated / administration & dosage*,  isolation & purification,  metabolism*,  therapeutic use
Metabolic Diseases / drug therapy,  metabolism
Reg. No./Substance:
0/Dietary Fats; 0/Linoleic Acids, Conjugated

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