| Conjugated linoleic acid evokes de-lipidation through the regulation of genes controlling lipid metabolism in adipose and liver tissue. | |
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MedLine Citation:
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PMID: 16045640 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Conjugated linoleic acid (CLA) is a unique lipid that elicits dramatic reductions in adiposity in several animal models when included at < or = 1% of the diet. Despite a flurry of investigations, the precise mechanisms by which conjugated linoleic acid elicits its dramatic effects in adipose tissue and liver are still largely unknown. In vivo and in vitro analyses of physiological modifications imparted by conjugated linoleic acid on protein and gene expression suggest that conjugated linoleic acid exerts its de-lipidating effects by modulating energy expenditure, apoptosis, fatty acid oxidation, lipolysis, stromal vascular cell differentiation and lipogenesis. The purpose of this review shall be to examine the recent advances and insights into conjugated linoleic acid's effects on obesity and lipid metabolism, specifically focused on changes in gene expression and physiology of liver and adipose tissue. |
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Authors:
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R L House; J P Cassady; E J Eisen; M K McIntosh; J Odle |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Obesity reviews : an official journal of the International Association for the Study of Obesity Volume: 6 ISSN: 1467-7881 ISO Abbreviation: Obes Rev Publication Date: 2005 Aug |
Date Detail:
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Created Date: 2005-07-27 Completed Date: 2005-10-25 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 100897395 Medline TA: Obes Rev Country: England |
Other Details:
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Languages: eng Pagination: 247-58 Citation Subset: IM |
Affiliation:
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Department of Animal Science & Functional Genomics Program, North Carolina State University, Raleigh, NC 27695, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue
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metabolism* Animals Cattle Energy Metabolism / drug effects Gene Expression Regulation / drug effects Humans Linoleic Acids, Conjugated / pharmacology* Lipid Metabolism* Liver / metabolism* Mice Obesity / genetics, metabolism* Organ Size / drug effects Rats |
| Chemical | |
Reg. No./Substance:
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0/Linoleic Acids, Conjugated |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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