Document Detail


Conjugated linoleic acid evokes de-lipidation through the regulation of genes controlling lipid metabolism in adipose and liver tissue.
MedLine Citation:
PMID:  16045640     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Conjugated linoleic acid (CLA) is a unique lipid that elicits dramatic reductions in adiposity in several animal models when included at < or = 1% of the diet. Despite a flurry of investigations, the precise mechanisms by which conjugated linoleic acid elicits its dramatic effects in adipose tissue and liver are still largely unknown. In vivo and in vitro analyses of physiological modifications imparted by conjugated linoleic acid on protein and gene expression suggest that conjugated linoleic acid exerts its de-lipidating effects by modulating energy expenditure, apoptosis, fatty acid oxidation, lipolysis, stromal vascular cell differentiation and lipogenesis. The purpose of this review shall be to examine the recent advances and insights into conjugated linoleic acid's effects on obesity and lipid metabolism, specifically focused on changes in gene expression and physiology of liver and adipose tissue.
Authors:
R L House; J P Cassady; E J Eisen; M K McIntosh; J Odle
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Obesity reviews : an official journal of the International Association for the Study of Obesity     Volume:  6     ISSN:  1467-7881     ISO Abbreviation:  Obes Rev     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-07-27     Completed Date:  2005-10-25     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  100897395     Medline TA:  Obes Rev     Country:  England    
Other Details:
Languages:  eng     Pagination:  247-58     Citation Subset:  IM    
Affiliation:
Department of Animal Science & Functional Genomics Program, North Carolina State University, Raleigh, NC 27695, USA.
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / metabolism*
Animals
Cattle
Energy Metabolism / drug effects
Gene Expression Regulation / drug effects
Humans
Linoleic Acids, Conjugated / pharmacology*
Lipid Metabolism*
Liver / metabolism*
Mice
Obesity / genetics,  metabolism*
Organ Size / drug effects
Rats
Chemical
Reg. No./Substance:
0/Linoleic Acids, Conjugated

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