| Conjugated linoleic acid (CLA) inhibits fatty acid synthetase activity in vitro. | |
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MedLine Citation:
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PMID: 12913306 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This paper describes the in vitro effect of conjugated linoleic acid (CLA) on fatty acid biosynthesis. Among the rat liver enzymes involved in fatty acid biosynthesis, fatty acid synthetase (FAS) showed the largest activity fluctuation with the types of fatty acids. Of the fatty acids, CLA was the most potent inhibitor of FAS, and the 9c, 11t-rather than the 10t, 12c-isomer showed greater inhibition. CLA also significantly lowered the incorporation of [14C]-acetate into phospholipid in breast cancer cells, supporting the view that CLA inhibits fatty acid biosynthesis through the interaction with FAS. |
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Authors:
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Hirosuke Oku; Sawitree Wongtangtintharn; Hironori Iwasaki; Takayoshi Toda |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Bioscience, biotechnology, and biochemistry Volume: 67 ISSN: 0916-8451 ISO Abbreviation: Biosci. Biotechnol. Biochem. Publication Date: 2003 Jul |
Date Detail:
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Created Date: 2003-08-12 Completed Date: 2004-05-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9205717 Medline TA: Biosci Biotechnol Biochem Country: Japan |
Other Details:
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Languages: eng Pagination: 1584-6 Citation Subset: IM |
Affiliation:
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Division of Molecular Biotechnology, Center of Molecular Bioscience, University of the Ryukyus, Nishihara, Okinawa, Japan. okuhiros@comb.u-ryukyu.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Fatty Acid Synthetase Complex / biosynthesis*, genetics, metabolism Fatty Acids / biosynthesis Linoleic Acids, Conjugated / pharmacology* Liver Rats |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids; 0/Linoleic Acids, Conjugated; EC 6.-/Fatty Acid Synthetase Complex |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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