Document Detail


Conjugated linoleic acid (CLA) inhibits fatty acid synthetase activity in vitro.
MedLine Citation:
PMID:  12913306     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This paper describes the in vitro effect of conjugated linoleic acid (CLA) on fatty acid biosynthesis. Among the rat liver enzymes involved in fatty acid biosynthesis, fatty acid synthetase (FAS) showed the largest activity fluctuation with the types of fatty acids. Of the fatty acids, CLA was the most potent inhibitor of FAS, and the 9c, 11t-rather than the 10t, 12c-isomer showed greater inhibition. CLA also significantly lowered the incorporation of [14C]-acetate into phospholipid in breast cancer cells, supporting the view that CLA inhibits fatty acid biosynthesis through the interaction with FAS.
Authors:
Hirosuke Oku; Sawitree Wongtangtintharn; Hironori Iwasaki; Takayoshi Toda
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bioscience, biotechnology, and biochemistry     Volume:  67     ISSN:  0916-8451     ISO Abbreviation:  Biosci. Biotechnol. Biochem.     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-08-12     Completed Date:  2004-05-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9205717     Medline TA:  Biosci Biotechnol Biochem     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1584-6     Citation Subset:  IM    
Affiliation:
Division of Molecular Biotechnology, Center of Molecular Bioscience, University of the Ryukyus, Nishihara, Okinawa, Japan. okuhiros@comb.u-ryukyu.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Animals
Fatty Acid Synthetase Complex / biosynthesis*,  genetics,  metabolism
Fatty Acids / biosynthesis
Linoleic Acids, Conjugated / pharmacology*
Liver
Rats
Chemical
Reg. No./Substance:
0/Fatty Acids; 0/Linoleic Acids, Conjugated; EC 6.-/Fatty Acid Synthetase Complex

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