Document Detail

Conjugated linoleic acid combined with creatine monohydrate and whey protein supplementation during strength training.
MedLine Citation:
PMID:  19403955     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The authors examined the combined effects of conjugated linoleic acid (CLA), creatine (C), and whey protein (P) supplementation during strength training. METHODS: Sixty-nine participants (52 men, 17 women; M +/- SD age 22.5 +/-2.5 yr) were randomly assigned (double-blind) to 1 of 3 groups: CCP (6 g/d CLA + 9 g/d C + 36 g/d P; n = 22), CP (C + P + placebo oil; n = 25), or P (P + placebo oil; n = 22) during 5 wk of strength training (4-5 sets, 6-12 repetitions, 6 d/wk). Measurements were taken for body composition (air-displacement plethysmography), muscle thickness (ultrasound) of the flexors and extensors of the elbow and knee, 1-repetition-maximum (1-RM) strength (leg press and bench press), urinary markers of bone resorption (N-telopeptides, NTx), myofibrillar protein catabolism (3-methylhistidine; 3-MH), oxidative stress (8-isoprostanes), and kidney function (microalbumin) before and after training. RESULTS: Contrast analyses indicated that the CCP group had a greater increase in bench-press (16.2% +/- 11.3% vs. 9.7% +/- 17.0%; p < .05) and leg-press (13.1% +/- 9.9% vs. 7.7% +/-14.2%; p < .05) strength and lean-tissue mass (2.4% +/- 2.8% vs. 1.3% +/-4.1%; p < .05) than the other groups combined. All groups increased muscle thickness over time (p < .05). The relative change in 3-MH (CCP -4.7% +/- 70.2%, CP -0.4% +/- 81.4%, P 20.3% +/- 75.2%) was less in the groups receiving creatine (p < .05), with the difference for NTx also close to significance (p = .055; CCP -3.4% +/- 66.6%, CP -3.9% +/- 64.9%, P 26.0% +/- 63.8%). There were no changes in oxidative stress or kidney function. CONCLUSION: Combining C, CLA, and P was beneficial for increasing strength and lean-tissue mass during heavy resistance training.
Stephen M Cornish; Darren G Candow; Nathan T Jantz; Philip D Chilibeck; Jonathan P Little; Scott Forbes; Saman Abeysekara; Gordon A Zello
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of sport nutrition and exercise metabolism     Volume:  19     ISSN:  1526-484X     ISO Abbreviation:  Int J Sport Nutr Exerc Metab     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-04-30     Completed Date:  2009-05-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100939812     Medline TA:  Int J Sport Nutr Exerc Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  79-96     Citation Subset:  IM    
College of Kinesiology, University of Saskatchewan, Saskatoon, SK, Canada.
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MeSH Terms
Body Composition / drug effects*,  physiology
Bone and Bones / metabolism
Creatine / administration & dosage*
Dietary Proteins / administration & dosage*
Dietary Supplements
Double-Blind Method
Drug Synergism
Kidney / drug effects,  physiology
Linoleic Acids, Conjugated / administration & dosage*
Milk Proteins / administration & dosage*
Muscle, Skeletal / drug effects,  metabolism,  physiology
Oxidative Stress / drug effects,  physiology
Resistance Training / methods*
Young Adult
Reg. No./Substance:
0/Dietary Proteins; 0/Linoleic Acids, Conjugated; 0/Milk Proteins; 0/whey protein; 57-00-1/Creatine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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