Document Detail

Conjugated hyperbilirubinemia in infancy associated with parenteral alimentation.
MedLine Citation:
PMID:  402457     Owner:  NLM     Status:  MEDLINE    
Liver biopsy was performed to exclude anatomic obstruction of the biliary tract in five prematurely born infants who had developed conjugated hyperbilirubinemia during intravenous alimentation with a protein hydrolysate. Each was being treated after having undergone a segmental intestinal resection for necrotizing enterocolitis. Bacterial and viral infections, metabolic disorders, and isoimmune hemolytic disease were excluded as possible causes of jaundice. Light microscopic and ultrastructural analysis disclosed cholestasis and hepatocellular injury without significant inflammatory reaction. Jaundice abated following permanent discontinuation of parenteral alimentation. The jaundice and cholestasis are interpreted to be hepatotoxic effects because of (1) their temporal relationship to the treatment and (2) the presence of hepatocellular damage.
J Bernstein; C H Chang; A J Brough; K P Heidelberger
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  90     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1977 Mar 
Date Detail:
Created Date:  1977-04-25     Completed Date:  1977-04-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  361-7     Citation Subset:  AIM; IM    
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MeSH Terms
Biopsy, Needle
Cholestasis / pathology
Hyperbilirubinemia / chemically induced*
Infant, Newborn
Infant, Premature, Diseases / chemically induced*
Liver / pathology
Parenteral Nutrition* / adverse effects
Parenteral Nutrition, Total* / adverse effects
Protein Hydrolysates / administration & dosage,  adverse effects*
Reg. No./Substance:
0/Protein Hydrolysates

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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