Document Detail

Conjugated glucocorticoids in amniotic fluid and fetal lung maturation.
MedLine Citation:
PMID:  263293     Owner:  NLM     Status:  MEDLINE    
While recent studies suggest that cortisol plays a role in lung maturation, conflicting reports have recently appeared relating cortisol in amniotic fluid to indices of lung maturation. the variation in the levels and differences in correlation appear to be due to differences in methodology, principally with respect to cross-reactivity in the radioimmunoassays with the conjugates of cortisol and corticosterone. We have found that the glucocorticoid conjugates correlate better with lung maturation (rs = 0.79) than does cortisol itself (rs = 0.58). This is probably because the conjugates are derived exclusively from the fetal compartment whereas cortisol is also produced by the chorionic membrane. In anencephaly, conjugate levels were very low while cortisol levels were relatively normal. Conjugate levels (mainly sulfates) appear promising as an adjunct to tests of fetal maturation.
B E Murphy
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  47     ISSN:  0021-972X     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  1978 Jul 
Date Detail:
Created Date:  1983-06-17     Completed Date:  1983-06-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  212-5     Citation Subset:  AIM; IM    
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MeSH Terms
Amniotic Fluid / analysis*
Anencephaly / diagnosis*,  physiopathology
Fetus / physiology
Gestational Age
Glucocorticoids / analysis*
Hydrocortisone / analysis*
Lung / embryology*
Reg. No./Substance:
0/Glucocorticoids; 50-23-7/Hydrocortisone

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