| Conjugated dihydroxy bile salt inhibition of glucose influx in rat jejunum in vitro. | |
| | |
MedLine Citation:
|
PMID: 855854 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Effects of bile salts on intestinal transfer differ in diverse animal preparations exposed to various bile acids. Radiolabeled glucose influx into rat jejunum in vitro was studied in buffer and compared to taurodeoxycholate, taurochenodeoxycholate, taurocholate, and deoxycholate. Jejunum was obtained from intact, bile-diverted, and colestipol-treated rats and in similar categories after abdominal x-irradiation. Taurodeoxycholate but not taurocholate inhibited glucose influx only in bile-fistula and colestipol-treated rats. Bile diversion increased and colestipol decreased glucose uptake from buffer. Added inhibitory effects of irradiation and bile salts were seen in bile-fistula animals. These data suggest that normal exposure to bile is chronically inhibiting jejunal glucose transport and that dihydroxy bile salts are responsible for this effect. They do not provide an explanation for the role of bile in the intestinal radiation syndrome. |
| | |
Authors:
|
E B Feldman; R Watt; D S Feldman |
Related Documents
:
|
7802594 - Biliary excretion of exogenous cadmium and manganese in long-evans cinnamon (lec) rats ... 2817224 - Hepatic recovery after biliary decompression of experimental obstructive jaundice. 188544 - Metabolism of [3h]-methylcholanthrene in the perfused rat liver. 2444184 - Bilirubin excretion into bile after partial hepatectomy in rats. 9192204 - Pro- and anti-oxidant parameters in rat liver after short-term exposure to hexachlorobe... 18272664 - Dysregulation of hepatic iron with aging: implications for heat stress-induced oxidativ... |
Publication Detail:
|
Type: In Vitro; Journal Article |
Journal Detail:
|
Title: The American journal of digestive diseases Volume: 22 ISSN: 0002-9211 ISO Abbreviation: Am J Dig Dis Publication Date: 1977 May |
Date Detail:
|
Created Date: 1977-06-22 Completed Date: 1977-06-22 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0404011 Medline TA: Am J Dig Dis Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 415-8 Citation Subset: AIM; IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Abdomen
/
radiation effects Animals Bile Acids and Salts / pharmacology* Biological Transport / drug effects Chenodeoxycholic Acid / analogs & derivatives, pharmacology Deoxycholic Acid / analogs & derivatives, pharmacology Glucose / metabolism* Intestinal Absorption / drug effects* Jejunum / drug effects, metabolism* Rats Taurocholic Acid / analogs & derivatives, pharmacology |
| Chemical | |
Reg. No./Substance:
|
0/Bile Acids and Salts; 474-25-9/Chenodeoxycholic Acid; 50-99-7/Glucose; 81-24-3/Taurocholic Acid; 83-44-3/Deoxycholic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effect of motilin on the lower esophageal sphincter of the opossum.
Next Document: Acute spontaneously recovering ulcerating colitis (ARUC). Report of 6 cases.