Document Detail

Conjugated catecholamines in rats transfused with perfluorocarbon blood substitute.
MedLine Citation:
PMID:  4094719     Owner:  NLM     Status:  MEDLINE    
The reappearance of circulating catecholamines (CAs) after transfusion with perfluorocarbon blood substitute and the importance of blood for CA conjugation were determined in rats. Arterial plasma concentrations of unconjugated (i.e. free), sulfoconjugated and glucuronoconjugated forms of the CAs dopamine (DA), noradrenaline (NA) and adrenaline (AD) in cannulated, anesthetized, control rats remained stable during the 4.5 h long experiments. Contrarily, in parallel experiments with another group of rats, replacement of blood by the perfluorocarbon blood substitute initially lowered the arterial concentrations of DA glucuronide, free AD and AD glucuronide; subsequently, free DA, NA and AD increased, followed by delayed increases in conjugated CA levels. These changes in CA concentrations preceded a fall in systemic arterial blood pressure (pa) and thus were not the consequences of hypotension.
J X Wilson; N H West; M Amies; E Michalska
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroscience letters     Volume:  62     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  1985 Dec 
Date Detail:
Created Date:  1986-04-21     Completed Date:  1986-04-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  329-33     Citation Subset:  IM    
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MeSH Terms
Blood Substitutes / administration & dosage*
Blood Transfusion* / methods
Catecholamines / blood*
Dopamine / blood
Epinephrine / blood
Fluorocarbons / administration & dosage*
Glucuronates / blood
Norepinephrine / blood
Rats, Inbred Strains
Sulfates / blood
Reg. No./Substance:
0/Blood Substitutes; 0/Catecholamines; 0/Fluorocarbons; 0/Glucuronates; 0/Sulfates; 311-89-7/perfluorotributylamine; 51-41-2/Norepinephrine; 51-43-4/Epinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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