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Conjugated Linoleic Acids Inhibit Hypoxia Inducible Factor-1α Stabilization under Hypoxic Condition in Human Hepatocellular Carcinoma Cells.
MedLine Citation:
PMID:  22975783     Owner:  NLM     Status:  In-Data-Review    
The anti-cancer effects of various fatty acids are drawing a lot of attention. To determine whether different fatty acids affect the hypoxic response of liver cancer cells, we examined the effects of various fatty acids on the stabilization of the hypoxia-inducible factor (HIF)-1α protein in the HepG2 human hepatocellular carcinoma (HCC) cell line under condition containing 1% O(2). Of the fatty acids examined, only 9cis, 11trans (c9, t11)-conjugated linoleic acid (CLA) and 10trans, 12cis (t10, c12)-CLA inhibited hypoxia-induced HIF-1α stabilization. In addition, HIF-1α prolyl hydroxylase or proteasome inhibition abrogated the effects of c9, t11- and t10, c12-CLA. Moreover, c9, t11- and t10, c12-CLA significantly inhibited cell proliferation and induced apoptotic cell death under hypoxia. This is the first study showing that c9, t11- and t10, c12-CLA inhibit the hypoxic response in HCC cells.
Masao Yamasaki; Taku Nagatomo; Tetsuya Matsuyama; Yuri Ikeho; Emiko Kato; Kei Nishiyama; Yoichi Sakakibara; Masahito Suiko; Kazuo Nishiyama
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of oleo science     Volume:  61     ISSN:  1347-3352     ISO Abbreviation:  J Oleo Sci     Publication Date:  2012  
Date Detail:
Created Date:  2012-09-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101175339     Medline TA:  J Oleo Sci     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  491-6     Citation Subset:  IM    
Division of Food Science and Nutrition, Department of Biochemistry and Applied Biosciences, Faculty of Agriculture, University of Miyazaki.
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