| Conjugated linoleic acid supplementation for 8 weeks does not affect body composition, lipid profile, or safety biomarkers in overweight, hyperlipidemic men. | |
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MedLine Citation:
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PMID: 21593349 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The usefulness of conjugated linoleic acid (CLA) as a nutraceutical remains ambiguous. Our objective was, therefore, to investigate the effect of CLA on body composition, blood lipids, and safety biomarkers in overweight, hyperlipidemic men. A double-blinded, 3-phase crossover trial was conducted in overweight (BMI ≥ 25 kg/m(2)), borderline hypercholesterolemic [LDL-cholesterol (C) ≥ 2.5 mmol/L] men aged 18-60 y. During three 8-wk phases, each separated by a 4-wk washout period, 27 participants consumed under supervision in random order 3.5 g/d of safflower oil (control), a 50:50 mixture of trans 10, cis 12 and cis 9, trans 11 (c9, t11) CLA:Clarinol G-80, and c9, t11 isomer:c9, t11 CLA. At baseline and endpoint of each phase, body weight, body fat mass, and lean body mass were measured by DXA. Blood lipid profiles and safety biomarkers, including insulin sensitivity, blood concentrations of adiponectin, and inflammatory (high sensitive-C-reactive protein, TNFα, and IL-6) and oxidative (oxidized-LDL) molecules, were measured. The effect of CLA consumption on fatty acid oxidation was also assessed. Compared with the control treatment, the CLA treatments did not affect changes in body weight, body composition, or blood lipids. In addition, CLA did not affect the β-oxidation rate of fatty acids or induce significant alterations in the safety markers tested. In conclusion, although no detrimental effects were caused by supplementation, these results do not confirm a role for CLA in either body weight or blood lipid regulation in humans. |
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Authors:
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Shama V Joseph; Hélène Jacques; Mélanie Plourde; Patricia L Mitchell; Roger S McLeod; Peter J H Jones |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2011-05-18 |
Journal Detail:
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Title: The Journal of nutrition Volume: 141 ISSN: 1541-6100 ISO Abbreviation: J. Nutr. Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-06-21 Completed Date: 2011-08-24 Revised Date: 2012-04-09 |
Medline Journal Info:
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Nlm Unique ID: 0404243 Medline TA: J Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 1286-91 Citation Subset: IM |
Affiliation:
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Department of Food Science and Nutrition, and Institute of Nutraceuticals and Functional Foods, Laval University, Quebec, QC G1V 0A6, Canada. |
| Data Bank Information | |
Bank Name/Acc. No.:
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ClinicalTrials.gov/NCT01047280 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adiponectin
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blood Adolescent Adult Biological Markers / blood Body Composition C-Reactive Protein / metabolism Cross-Over Studies Dietary Supplements* / adverse effects Double-Blind Method Humans Hyperlipidemias / blood, complications, diet therapy* Inflammation Mediators / blood Insulin Resistance Interleukin-6 / blood Linoleic Acids, Conjugated / administration & dosage* Lipids / blood, chemistry Male Middle Aged Overweight / blood, complications, diet therapy* Oxidation-Reduction Tumor Necrosis Factor-alpha / blood Young Adult |
| Chemical | |
Reg. No./Substance:
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0/ADIPOQ protein, human; 0/Adiponectin; 0/Biological Markers; 0/IL6 protein, human; 0/Inflammation Mediators; 0/Interleukin-6; 0/Linoleic Acids, Conjugated; 0/Lipids; 0/Tumor Necrosis Factor-alpha; 9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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