Document Detail


Conjugated linoleic acid ameliorates inflammation-induced colorectal cancer in mice through activation of PPARgamma.
MedLine Citation:
PMID:  20089779     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Conjugated linoleic acid (CLA) exerts a protective effect on experimental inflammatory bowel disease and shows promise as a chemopreventive agent against colorectal cancer (CRC) in mice, although the mechanisms by which it exerts its beneficial effects against malignancies in the gut are not completely understood. Mice lacking PPARgamma in immune and epithelial cells and PPARgamma-expressing littermates were fed either control or CLA-supplemented (1 g CLA/100 g) diets to determine the role of PPARgamma in inflammation-induced CRC. To induce tumor formation and colitis, mice were treated with azoxymethane and then challenged with 2% dextran sodium sulfate, respectively. Dietary CLA ameliorated disease activity, decreased colitis, and prevented adenocarcinoma formation in the PPARgamma-expressing floxed mice but not in the tissue-specific PPARgamma-null mice. Dietary CLA supplementation significantly decreased the percentages of macrophages in the mesenteric lymph nodes (MLN) regardless of the genotype and increased regulatory T cell numbers in MLN of PPARgamma-expressing, but not in the tissue-specific, PPARgamma-null mice. Colonic tumor necrosis factor-alpha mRNA expression was significantly suppressed in CLA-fed, PPARgamma-expressing mice. This study suggests CLA ameliorates colitis and prevents tumor formation in part through a PPARgamma-dependent mechanism.
Authors:
Nicholas P Evans; Sarah A Misyak; Eva M Schmelz; Amir J Guri; Raquel Hontecillas; Josep Bassaganya-Riera
Related Documents :
9003009 - Fasting prevents experimental murine colitis produced by dextran sulfate sodium and dec...
18172719 - Tip-alpha (hp0596 gene product) is a highly immunogenic helicobacter pylori protein inv...
19299579 - Cholinergic giant migrating contractions in conscious mouse colon assessed by using a n...
4567309 - Colonization resistance of the digestive tract of mice during systemic antibiotic treat...
20300439 - Anti-inflammatory effects of inonotus obliquus in colitis induced by dextran sodium sul...
568579 - Induction of granulomas in mice by crohn's disease tissue.
20689579 - App intracellular domain impairs adult neurogenesis in transgenic mice by inducing neur...
2351839 - Increased monoclonal antibody ascites production in mice primed with freund's incomplet...
15706229 - Mastication influences the survival of newly generated cells in mouse dentate gyrus.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-01-20
Journal Detail:
Title:  The Journal of nutrition     Volume:  140     ISSN:  1541-6100     ISO Abbreviation:  J. Nutr.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-02-22     Completed Date:  2010-03-25     Revised Date:  2013-05-31    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  515-21     Citation Subset:  IM    
Affiliation:
Nutritional Immunology and Molecular Nutrition Laboratory, Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Cell Line
Colorectal Neoplasms / drug therapy*
Diet
Epithelial Cells / drug effects,  metabolism
Gene Expression Regulation / drug effects*
Inflammation / complications*
Inflammatory Bowel Diseases / drug therapy
Linoleic Acids, Conjugated / administration & dosage,  pharmacology*
Lymph Nodes / drug effects
Macrophages / drug effects,  metabolism
Mice
Mice, Knockout
PPAR gamma / metabolism*
Grant Support
ID/Acronym/Agency:
5R01AT4308/AT/NCCAM NIH HHS
Chemical
Reg. No./Substance:
0/Linoleic Acids, Conjugated; 0/PPAR gamma
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Infant Birth Size Is Not Associated with Maternal Intake and Status of Folate during Second Trimeste...
Next Document:  Constipation Is Relieved More by Rye Bread Than Wheat Bread or Laxatives without Increased Adverse G...