Document Detail

Conjugated linoleic acid ameliorates inflammation-induced colorectal cancer in mice through activation of PPARgamma.
MedLine Citation:
PMID:  20089779     Owner:  NLM     Status:  MEDLINE    
Conjugated linoleic acid (CLA) exerts a protective effect on experimental inflammatory bowel disease and shows promise as a chemopreventive agent against colorectal cancer (CRC) in mice, although the mechanisms by which it exerts its beneficial effects against malignancies in the gut are not completely understood. Mice lacking PPARgamma in immune and epithelial cells and PPARgamma-expressing littermates were fed either control or CLA-supplemented (1 g CLA/100 g) diets to determine the role of PPARgamma in inflammation-induced CRC. To induce tumor formation and colitis, mice were treated with azoxymethane and then challenged with 2% dextran sodium sulfate, respectively. Dietary CLA ameliorated disease activity, decreased colitis, and prevented adenocarcinoma formation in the PPARgamma-expressing floxed mice but not in the tissue-specific PPARgamma-null mice. Dietary CLA supplementation significantly decreased the percentages of macrophages in the mesenteric lymph nodes (MLN) regardless of the genotype and increased regulatory T cell numbers in MLN of PPARgamma-expressing, but not in the tissue-specific, PPARgamma-null mice. Colonic tumor necrosis factor-alpha mRNA expression was significantly suppressed in CLA-fed, PPARgamma-expressing mice. This study suggests CLA ameliorates colitis and prevents tumor formation in part through a PPARgamma-dependent mechanism.
Nicholas P Evans; Sarah A Misyak; Eva M Schmelz; Amir J Guri; Raquel Hontecillas; Josep Bassaganya-Riera
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-01-20
Journal Detail:
Title:  The Journal of nutrition     Volume:  140     ISSN:  1541-6100     ISO Abbreviation:  J. Nutr.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-02-22     Completed Date:  2010-03-25     Revised Date:  2013-05-31    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  515-21     Citation Subset:  IM    
Nutritional Immunology and Molecular Nutrition Laboratory, Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.
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MeSH Terms
Cell Line
Colorectal Neoplasms / drug therapy*
Epithelial Cells / drug effects,  metabolism
Gene Expression Regulation / drug effects*
Inflammation / complications*
Inflammatory Bowel Diseases / drug therapy
Linoleic Acids, Conjugated / administration & dosage,  pharmacology*
Lymph Nodes / drug effects
Macrophages / drug effects,  metabolism
Mice, Knockout
PPAR gamma / metabolism*
Grant Support
Reg. No./Substance:
0/Linoleic Acids, Conjugated; 0/PPAR gamma

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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