Document Detail

Conjugated bile acids associate with altered rates of glucose and lipid oxidation after Roux-en-Y gastric bypass.
MedLine Citation:
PMID:  22638681     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Laparoscopic Roux-en-Y gastric bypass (RYGB) induces a more favorable metabolic profile than expected by weight loss alone. In this study, we investigated the effect of RYGB on serum bile acid levels and their relation to clinical outcomes.
METHODS: We included 30 obese patients who underwent RYGB (BMI = 46.1 ± 5.9 kg/m(2)). Clinical measurements and laboratory determinations were performed before surgery and 1 year after surgery. Fasting serum bile acids were measured by an enzymatic method and individual bile acids were quantified by HLPC-tandem mass spectrometry. Indirect calorimetry was performed to measure the rates of energy expenditure and substrate oxidation.
RESULTS: Fasting total serum bile acid levels increased twofold after RYGB (pre, 3.68 ± 2.03 vs. post, 7.06 ± 9.65 μmol/l, +92 %, p = 0.002). This increase in total bile acids was accompanied by a decrease in conjugated bile acids, which correlated with decreased glucose oxidation (r = 0.571, p = 0.002) and with increased lipid oxidation (r = -0.626, p = 0.0004). The change in taurine-conjugated bile acids correlated with altered DIO2 mRNA expression in adipose tissue (r = -0.498, p = 0.013) potentially linking bile acid conjugation to substrate oxidation through DIO2.
CONCLUSIONS: Fasting serum bile acid levels increase after RYGB. More specifically, changes in bile acid conjugation after RYGB associate with altered energy metabolism.
M Simonen; N Dali-Youcef; D Kaminska; S Venesmaa; P Käkelä; M Pääkkönen; M Hallikainen; M Kolehmainen; M Uusitupa; L Moilanen; M Laakso; H Gylling; M E Patti; J Auwerx; Jussi Pihlajamäki
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Obesity surgery     Volume:  22     ISSN:  1708-0428     ISO Abbreviation:  Obes Surg     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-28     Completed Date:  2013-01-03     Revised Date:  2013-12-02    
Medline Journal Info:
Nlm Unique ID:  9106714     Medline TA:  Obes Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1473-80     Citation Subset:  IM    
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MeSH Terms
Adipose Tissue / metabolism*
Bile Acids and Salts / blood*
Biological Markers / blood
Blood Glucose / metabolism
Body Mass Index
Energy Metabolism
Gastric Bypass*
Glucose / metabolism*
Lipid Metabolism
Liver / metabolism*
Longitudinal Studies
Middle Aged
Obesity, Morbid / blood*,  surgery*
Treatment Outcome
Grant Support
231138//European Research Council
Reg. No./Substance:
0/Bile Acids and Salts; 0/Biological Markers; 0/Blood Glucose; IY9XDZ35W2/Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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