| Conjugate addition of isocyanides to chromone 3-carboxylic acid: an efficient one-pot synthesis of chroman-4-one 2-carboxamides. | |
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MedLine Citation:
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PMID: 22434156 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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We report a novel Lewis acid catalysed tandem reaction of isocyanides, chromone 3-carboxylic acid and nucleophiles. An experimentally very simple procedure, involving the use of microwave irradiation in the presence of a Lewis acid catalyst, affords a representative collection of chromone-2-carboxamides and chromone-2-carboxamido-3-esters in high yields, in just a few minutes. Such an unprecedented strategy is formally equivalent to a conjugate addition of isocyanides to Michael acceptors. |
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Authors:
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Ana G Neo; Jesús Díaz; Stefano Marcaccini; Carlos F Marcos |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-3-21 |
Journal Detail:
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Title: Organic & biomolecular chemistry Volume: - ISSN: 1477-0539 ISO Abbreviation: - Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-3-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101154995 Medline TA: Org Biomol Chem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Laboratorio de Química Orgánica y Bioorgánica (L.O.B.O.), Dept Química Orgánica e Inorgánica, Facultad de Veterinaria, Universidad de Extremadura, 10071 Cáceres, Spain. cfernan@unex.es. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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